Epigenetics & Nuclear Signaling Antibodies 1
Anti-CEBPE Antibody (CAB13960)
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- SKU:
- CAB13960
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-CEBPE Antibody |
| Antibody SKU: | CAB13960 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human CEBPE (NP_001796.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Raji, Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human CEBPE (NP_001796.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSHG TYYE CEPR GGQQ PLEF SGGR AGPG ELGD MCEH EASI DLSA YIES GEEQ LLSD LFAV KPAP EARG LKGP GTPA FPHY LPPD PRPF AYPP HTFG PDRK ALGP GIYS SPGS YDPR AVAV KEEP RGPE GSRA ASRG SYNP LQYQ VAHC GQTA MHLP PTLA APGQ PLRV LKAP LATA APPC SPLL KAPS PA |
| Gene ID: | 1053 |
| Uniprot: | Q15744 |
| Cellular Location: | Nucleus |
| Calculated MW: | 30kDa |
| Observed MW: | 30-35kDa |
| Synonyms: | CEBPE, C/EBP-epsilon, CRP1 |
| Background: | The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. |
| UniProt Protein Function: | C/EBP-epsilon: C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Belongs to the bZIP family. C/EBP subfamily. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: nucleoplasm Biological Process: defense response; positive regulation of transcription from RNA polymerase II promoter Disease: Specific Granule Deficiency |
| NCBI Summary: | The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15744 |
| NCBI GenInfo Identifier: | 62512175 |
| NCBI Gene ID: | 1053 |
| NCBI Accession: | Q15744.2 |
| UniProt Secondary Accession: | Q15744,Q15745, Q8IYI2, Q99803, |
| UniProt Related Accession: | Q15744 |
| Molecular Weight: | 30,603 Da |
| NCBI Full Name: | CCAAT/enhancer-binding protein epsilon |
| NCBI Synonym Full Names: | CCAAT/enhancer binding protein epsilon |
| NCBI Official Symbol: | CEBPE |
| NCBI Official Synonym Symbols: | CRP1; C/EBP-epsilon |
| NCBI Protein Information: | CCAAT/enhancer-binding protein epsilon |
| UniProt Protein Name: | CCAAT/enhancer-binding protein epsilon |
| Protein Family: | CCAAT/enhancer-binding protein |
| UniProt Gene Name: | CEBPE |
| UniProt Entry Name: | CEBPE_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CEBPE antibody (CAB13960) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat spleen using CEBPE Antibody (CAB13960) at dilution of 1:100 (40x lens). |
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