Cell Death Antibodies 2
Anti-CEACAM6 Antibody (CAB8440)
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- SKU:
- CAB8440
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-CEACAM6 Antibody |
| Antibody SKU: | CAB8440 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-320 of human CEACAM6 (NP_002474.4). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, Raji, HeLa, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-320 of human CEACAM6 (NP_002474.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LTLL SVKR NDAG SYEC EIQN PASA NRSD PVTL NVLY GPDV PTIS PSKA NYRP GENL NLSC HAAS NPPA QYSW FING TFQQ STQE LFIP NITV NNSG SYMC QAHN SATG LNRT TVTM ITVS G |
| Gene ID: | 4680 |
| Uniprot: | P40199 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor |
| Calculated MW: | 37kDa |
| Observed MW: | 110kDa |
| Synonyms: | CEACAM6, CD66c, CEAL, NCA |
| Background: | This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. |
| UniProt Protein Function: | CEACAM6: Belongs to the immunoglobulin superfamily. CEA family |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: extracellular space; integral to plasma membrane; plasma membrane Molecular Function:protein binding Biological Process: cell-cell signaling; leukocyte migration; signal transduction |
| NCBI Summary: | This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014] |
| UniProt Code: | P40199 |
| NCBI GenInfo Identifier: | 296439410 |
| NCBI Gene ID: | 4680 |
| NCBI Accession: | P40199.3 |
| UniProt Secondary Accession: | P40199,Q13774, Q14920, Q53XP7, |
| UniProt Related Accession: | P40199 |
| Molecular Weight: | 37,195 Da |
| NCBI Full Name: | Carcinoembryonic antigen-related cell adhesion molecule 6 |
| NCBI Synonym Full Names: | carcinoembryonic antigen related cell adhesion molecule 6 |
| NCBI Official Symbol: | CEACAM6 |
| NCBI Official Synonym Symbols: | NCA; CEAL; CD66c |
| NCBI Protein Information: | carcinoembryonic antigen-related cell adhesion molecule 6 |
| UniProt Protein Name: | Carcinoembryonic antigen-related cell adhesion molecule 6 |
| UniProt Synonym Protein Names: | Non-specific crossreacting antigen; Normal cross-reacting antigen; CD_antigen: CD66c |
| Protein Family: | Carcinoembryonic antigen-related cell adhesion molecule |
| UniProt Gene Name: | CEACAM6 |
| UniProt Entry Name: | CEAM6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CEACAM6 antibody (CAB8440) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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