Cell Death Antibodies 1
Anti-CEACAM5 Antibody (CAB12421)
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- SKU:
- CAB12421
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-CEACAM5 Antibody |
| Antibody SKU: | CAB12421 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human CEACAM5 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse pancreas |
| Immunogen: | Recombinant protein of human CEACAM5 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1048 |
| Uniprot: | P06731 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor |
| Calculated MW: | 76kDa |
| Observed MW: | 150kDa |
| Synonyms: | CEACAM5, CD66e, CEA |
| Background: | This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CEACAM5: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily. CEA family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Immunoglobulin superfamily; Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 19q13.1-q13.2 Cellular Component: basolateral plasma membrane; integral to plasma membrane Molecular Function:identical protein binding; protein homodimerization activity Biological Process: homotypic cell-cell adhesion; negative regulation of apoptosis |
| NCBI Summary: | Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the CEA gene family, see CEACAM1 (MIM 109770).[supplied by OMIM, Oct 2009] |
| UniProt Code: | P06731 |
| NCBI GenInfo Identifier: | 317373456 |
| NCBI Gene ID: | 1048 |
| NCBI Accession: | P06731.3 |
| UniProt Secondary Accession: | P06731,H9KVA7, |
| UniProt Related Accession: | P06731 |
| Molecular Weight: | 76,795 Da |
| NCBI Full Name: | Carcinoembryonic antigen-related cell adhesion molecule 5 |
| NCBI Synonym Full Names: | carcinoembryonic antigen-related cell adhesion molecule 5 |
| NCBI Official Symbol: | CEACAM5 |
| NCBI Official Synonym Symbols: | CEA; CD66e |
| NCBI Protein Information: | carcinoembryonic antigen-related cell adhesion molecule 5; meconium antigen 100 |
| UniProt Protein Name: | Carcinoembryonic antigen-related cell adhesion molecule 5 |
| UniProt Synonym Protein Names: | Carcinoembryonic antigen; CEA; Meconium antigen 100 |
| Protein Family: | Colicin |
| UniProt Gene Name: | CEACAM5 |
| UniProt Entry Name: | CEAM5_HUMAN |
 | Western blot analysis of extracts of mouse pancreas, using CEACAM5 antibody (CAB12421) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded mouse brain using CEACAM5 antibody (CAB12421) (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using CEACAM5 antibody (CAB12421) (40x lens). |
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