Cell Biology Antibodies 3
Anti-CDY2B Antibody (CAB12662)
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- SKU:
- CAB12662
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CDY2B Antibody |
| Antibody SKU: | CAB12662 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human CDY2B (NP_001001722.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:3000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, Mouse kidney, Rat kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human CDY2B (NP_001001722.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MASQ EFEV EAIV DKRQ DKNG NTQY LVRW KGYD KQDD TWEP EQHL MNCE KCVH DFNR RQTE KQKK LTWT TTSR IFSN NARR RTSR STKA NYSK NSPK TPVT DKHH RSKN CKLF AASK NVRR KAAS TLSD TKNM EIIN STIE TLAP DSPF DHKK TVSG FQKL EKLD PIAA DQQD TVVF KVTE GKLL RDPL SHPG AEQT GIQN KTQM HPLM SQMS GSVT ASMA TGSA TRKG IVVL IDPL AANG TTDM HTSV PRVK GGQR NITD DSRG QPFI KKMH FTIR LTES |
| Gene ID: | 203611 |
| Uniprot: | Q9Y6F7 |
| Cellular Location: | Nucleus |
| Calculated MW: | 60kDa |
| Observed MW: | 60kDa |
| Synonyms: | CDY2B, CDY |
| Background: | This intronless gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. Two nearly identical copies of this gene are found in a palindromic region on chromosome Y; this record represents the centromeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. |
| UniProt Protein Function: | CDY2A: May have histone acetyltransferase activity. |
| UniProt Protein Details: | Protein type:Acetyltransferase; EC 2.3.1.48 Chromosomal Location of Human Ortholog: Yq11.222 Biological Process: spermatogenesis Disease: Spermatogenic Failure, Y-linked, 2 |
| NCBI Summary: | This intronless gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. Two nearly identical copies of this gene are found in a palindromic region on chromosome Y; this record represents the centromeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y6F7 |
| NCBI GenInfo Identifier: | 20138088 |
| NCBI Gene ID: | 203611 |
| NCBI Accession: | Q9Y6F7.1 |
| UniProt Secondary Accession: | Q9Y6F7,A8K868, |
| UniProt Related Accession: | Q9Y6F7 |
| Molecular Weight: | 61kDa |
| NCBI Full Name: | Testis-specific chromodomain protein Y 2 |
| NCBI Synonym Full Names: | chromodomain Y-linked 2B |
| NCBI Official Symbol: | CDY2B |
| NCBI Official Synonym Symbols: | CDY |
| NCBI Protein Information: | testis-specific chromodomain protein Y 2 |
| UniProt Protein Name: | Testis-specific chromodomain protein Y 2 |
| UniProt Gene Name: | CDY2A |
 | Western blot analysis of extracts of various cell lines, using CDY2B antibody (CAB12662) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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