Cell Biology Antibodies 12

Anti-CDY1 Antibody (CAB9854)

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SKU:
CAB9854
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CDY1 Antibody
Antibody SKU:CAB9854
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human CDY1 (NP_004671.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, A-431, HeLa, LO2, U-87MG, Mouse brain, Mouse lung, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human CDY1 (NP_004671.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASQ EFEV EAIV DKRQ DKNG NTQY LVRW KGYD KQDD TWEP EQHL MNCE KCVH DFNR RQTE KQKK LTWT TTSR IFSN NARR RTSR STKA NYSK NSPK TPVT DKHH RSKN RKLF AASK NVRR KAAS ILSD TKNM EIIN STIE TLAP DSPF DHKT VSGF QKLE KLDP IAAD QQDT VVFK VTEG KLLR DPLS RPGA EQTG IQNK TQIH PLMS QM
Gene ID:9085
Uniprot:Q9Y6F8
Cellular Location:Nucleus
Calculated MW:60kDa/62kDa
Observed MW:70kDa
Synonyms:CDY1, CDY, CDY1A
Background:This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined.
UniProt Protein Function:CDY1: Has histone acetyltransferase activity, with a preference for histone H4. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Acetyltransferase; EC 2.3.1.48

Chromosomal Location of Human Ortholog: Yq11.23

Cellular Component: nucleus

Molecular Function:methylated histone residue binding

Biological Process: spermatogenesis

Disease: Spermatogenic Failure, Y-linked, 2

NCBI Summary:This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more centromeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y6F8
NCBI GenInfo Identifier:20138089
NCBI Gene ID:253175
NCBI Accession:Q9Y6F8.1
UniProt Secondary Accession:Q9Y6F8,O14600, A2RUK1,
UniProt Related Accession:Q9Y6F8
Molecular Weight:62,017 Da
NCBI Full Name:Testis-specific chromodomain protein Y 1
NCBI Synonym Full Names:chromodomain Y-linked 1B
NCBI Official Symbol:CDY1B  
NCBI Official Synonym Symbols:CDY  
NCBI Protein Information:testis-specific chromodomain protein Y 1
UniProt Protein Name:Testis-specific chromodomain protein Y 1
Protein Family:Testis-specific chromodomain protein
UniProt Gene Name:CDY1  
UniProt Entry Name:CDY1_HUMAN
Anti-CDY1 Polyclonal Antibody (CAB9854)Western blot analysis of extracts of various cell lines, using CDY1 antibody (CAB9854) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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