Metabolism Antibodies 2

Anti-CDS2 Antibody (CAB4248)

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SKU:
CAB4248
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism

Description

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Antibody Name:Anti-CDS2 Antibody
Antibody SKU:CAB4248
Antibody Size:100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic Peptide of human CDS2
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HepG2
Immunogen:A synthetic Peptide of human CDS2
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8760
Uniprot:O95674
Cellular Location:Matrix side, Mitochondrion inner membrane, Multi-pass membrane protein
Calculated MW:29kDa/51kDa
Observed MW:55kDa
Synonyms:CDS2
Background:Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13.
UniProt Protein Function:CDS2: Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. Belongs to the CDS family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Lipid Metabolism - glycerophospholipid; Mitochondrial; Transferase; Membrane protein, multi-pass; Endoplasmic reticulum; EC 2.7.7.41; Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: membrane; endoplasmic reticulum; mitochondrial inner membrane; integral to membrane

Molecular Function:phosphatidate cytidylyltransferase activity

Biological Process: phosphatidylglycerol biosynthetic process; phospholipid metabolic process; glycerophospholipid biosynthetic process; CDP-diacylglycerol biosynthetic process

NCBI Summary:Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]
UniProt Code:O95674
NCBI GenInfo Identifier:7673965
NCBI Gene ID:8760
NCBI Accession:O95674.1
UniProt Secondary Accession:O95674,Q99L43,
UniProt Related Accession:O95674
Molecular Weight:445
NCBI Full Name:Phosphatidate cytidylyltransferase 2
NCBI Synonym Full Names:CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
NCBI Official Symbol:CDS2  
NCBI Protein Information:phosphatidate cytidylyltransferase 2; CDS 2; CDP-DG synthase 2; CDP-DAG synthase 2; CDP-DG synthetase 2; CDP-diglyceride synthase 2; CDP-diglyceride synthetase 2; CDP-diacylglycerol synthase 2; CDP-diglyceride diphosphorylase 2; CDP-diglyceride pyrophosph
UniProt Protein Name:Phosphatidate cytidylyltransferase 2
UniProt Synonym Protein Names:CDP-DAG synthase 2; CDP-DG synthase 2; CDP-diacylglycerol synthase 2; CDS 2; CDP-diglyceride pyrophosphorylase 2; CDP-diglyceride synthase 2; CTP:phosphatidate cytidylyltransferase 2
Protein Family:Phosphatidate cytidylyltransferase
UniProt Gene Name:CDS2  
UniProt Entry Name:CDS2_HUMAN
Anti-CDS2 Antibody (CAB4248)Western blot analysis of extracts of HepG2 cells, using CDS2 antibody (CAB4248). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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