Metabolism Antibodies 1

Anti-CDS1 Antibody (CAB13758)

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SKU:
CAB13758
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-CDS1 Antibody
Antibody SKU:CAB13758
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human CDS1 (NP_001254.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:OVCAR3, U-87MG, 293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human CDS1 (NP_001254.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MLEL RHRG SCPG PREA VSPP HREG EAAG GDHE TEST SDKE TDID DRYG DLDS RTDS DIPE IPPS SDRT PEIL KKAL SGLS
Gene ID:1040
Uniprot:Q92903
Cellular Location:Endoplasmic reticulum membrane, Multi-pass membrane protein
Calculated MW:53kDa
Observed MW:57kDa
Synonyms:CDS1, CDS
Background:Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13.
UniProt Code:Q92903
NCBI GenInfo Identifier:22035624
NCBI Gene ID:1040
NCBI Accession:NP_001254
UniProt Secondary Accession:Q92903,O00163, B2RAL5,
UniProt Related Accession:Q92903
Molecular Weight:53,304 Da
NCBI Full Name:phosphatidate cytidylyltransferase 1
NCBI Synonym Full Names:CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
NCBI Official Symbol:CDS1  
NCBI Official Synonym Symbols:CDS  
NCBI Protein Information:phosphatidate cytidylyltransferase 1; CDP-DAG synthase 1; CDP-DG synthase 1; CDP-DG synthetase 1; CDP-diacylglycerol synthase 1; CDP-diglyceride pyrophosphorylase 1; CDP-diglyceride synthase 1; CDP-diglyceride synthetase 1; CDS 1; CTP:phosphatidate cytidy
UniProt Protein Name:Phosphatidate cytidylyltransferase 1
UniProt Synonym Protein Names:CDP-DAG synthase 1; CDP-DG synthase 1; CDP-diacylglycerol synthase 1; CDS 1; CDP-diglyceride pyrophosphorylase 1; CDP-diglyceride synthase 1; CTP:phosphatidate cytidylyltransferase 1
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:CDS1  
UniProt Entry Name:CDS1_HUMAN
Anti-CDS1 Antibody (CAB13758)Western blot analysis of extracts of various cell lines, using CDS1 antibody (CAB13758) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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