Cell Biology Antibodies 6

Anti-CDON Antibody (CAB15830)

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SKU:
CAB15830
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-CDON Antibody
Antibody SKU:CAB15830
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 520-720 of human CDON (NP_001230526.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T, NIH/3T3
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 520-720 of human CDON (NP_001230526.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FETN TKAE TVTL PDAA QNDD RSKR DGSE TGLL SSFP VKVH PSAV ESAP EKNA SGIS VPDA PIIL SPPQ THTP DTYN LVWR AGKD GGLP INAY FVKY RKLD DGVG MLGS WHTV RVPG SENE LHLA ELEP SSLY EVLM VARS AAGE GQPA MLTF RTSK EKTA SSKN TQAS SPPV GIPK YPVV SEAA NNNF GVVL TDSS RHSG V
Gene ID:50937
Uniprot:Q4KMG0
Cellular Location:Cell membrane, Single-pass membrane protein
Calculated MW:136kDa/139kDa
Observed MW:150kDa
Synonyms:CDON, CDO, CDON1, HPE11, ORCAM
Background:This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis.
UniProt Protein Function:CDON: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Defects in CDON are the cause of holoprosencephaly type 11 (HPE11). HPE11 is a structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11q24.2

Cellular Component: extracellular matrix; integral to membrane; plasma membrane

Molecular Function:protein binding

Biological Process: lens development in camera-type eye; regulation of protein heterodimerization activity; smoothened signaling pathway; satellite cell differentiation; cell fate specification; positive regulation of skeletal muscle development; anterior/posterior pattern formation; positive regulation of small GTPase mediated signal transduction; muscle cell differentiation; embryonic body morphogenesis; positive regulation of MAPKKK cascade; embryonic retina morphogenesis in camera-type eye; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; cerebral cortex development; cell adhesion; positive regulation of neuron differentiation; myoblast fusion

Disease: Holoprosencephaly 11

NCBI Summary:This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]
UniProt Code:Q4KMG0
NCBI GenInfo Identifier:308153422
NCBI Gene ID:50937
NCBI Accession:Q4KMG0.2
UniProt Secondary Accession:Q4KMG0,O14631,
UniProt Related Accession:Q4KMG0
Molecular Weight:136,527 Da
NCBI Full Name:Cell adhesion molecule-related/down-regulated by oncogenes
NCBI Synonym Full Names:cell adhesion associated, oncogene regulated
NCBI Official Symbol:CDON  
NCBI Official Synonym Symbols:CDO; CDON1; HPE11; ORCAM  
NCBI Protein Information:cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog; surface glycoprotein, Ig superfamily member
UniProt Protein Name:Cell adhesion molecule-related/down-regulated by oncogenes
Protein Family:Cell adhesion molecule-related/down-regulated by oncogenes
UniProt Gene Name:CDON  
UniProt Entry Name:CDON_HUMAN
Anti-CDON Antibody (CAB15830)Western blot analysis of extracts of various cell lines, using CDON antibody (CAB15830) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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