Cell Cycle Antibodies 1
Anti-CDKN3 Antibody (CAB2061)
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- SKU:
- CAB2061
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-CDKN3 Antibody |
| Antibody SKU: | CAB2061 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human CDKN3 (NP_001124323.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human CDKN3 (NP_001124323.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKPP SSIQ TSCK FKDV RRNV QKDT EELK SCGI QDIF VFCT RGEL SKYR VPNL LDLY QQCG IITH HHPI ADGG TPDI ASCC EIME ELTT CLKN YRKT LIHC YGGL GRSC LVAA CLLL YLSD TISP EQAI DSLR DLRG SGAI QTIK QYNY LHEF RDKL AAHL SSRD SQSR SVSR |
| Gene ID: | 1033 |
| Uniprot: | Q16667 |
| Cellular Location: | Cytoplasm, perinuclear region |
| Calculated MW: | 19kDa/23kDa |
| Observed MW: | 23kDa |
| Synonyms: | CDKN3, CDI1, CIP2, KAP, KAP1 |
| Background: | The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CDKN3: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner. Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC). Belongs to the protein-tyrosine phosphatase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.16; Cell cycle regulation; EC 3.1.3.48 Chromosomal Location of Human Ortholog: 14q22 Cellular Component: perinuclear region of cytoplasm; cytoplasm Molecular Function:protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein serine/threonine phosphatase activity Biological Process: negative regulation of cell proliferation; regulation of cyclin-dependent protein kinase activity; cell cycle arrest; G1/S transition of mitotic cell cycle Disease: Hepatocellular Carcinoma |
| NCBI Summary: | The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| UniProt Code: | Q16667 |
| NCBI GenInfo Identifier: | 2499769 |
| NCBI Gene ID: | 1033 |
| NCBI Accession: | Q16667.1 |
| UniProt Related Accession: | Q16667 |
| Molecular Weight: | 23805 Da |
| NCBI Full Name: | Cyclin-dependent kinase inhibitor 3 |
| NCBI Synonym Full Names: | cyclin dependent kinase inhibitor 3 |
| NCBI Official Symbol: | CDKN3 |
| NCBI Official Synonym Symbols: | KAP; CDI1; CIP2; KAP1 |
| NCBI Protein Information: | cyclin-dependent kinase inhibitor 3 |
| UniProt Protein Name: | Cyclin-dependent kinase inhibitor 3 |
| UniProt Synonym Protein Names: | CDK2-associated dual-specificity phosphatase; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting protein 2; Kinase-associated phosphatase |
| Protein Family: | Cyclin-dependent kinase inhibitor |
| UniProt Gene Name: | CDKN3 |
| UniProt Entry Name: | CDKN3_HUMAN |
 | Western blot analysis of extracts of mouse liver, using CDKN3 antibody (CAB2061) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunofluorescence analysis of MCF-7 cells using CDKN3 antibody (CAB2061). Blue: DAPI for nuclear staining. |
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