Cell Cycle Antibodies 2

Anti-CDKN2C/p18-INK4C Antibody (CAB8751)

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SKU:
CAB8751
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Cycle

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-CDKN2C/p18-INK4C Antibody
Antibody SKU:CAB8751
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CDKN2C/p18-INK4C
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, 293T, NIH/3T3, Mouse lung, Mouse testis, Rat spleen, Rat kidney
Immunogen:A synthesized peptide derived from human CDKN2C/p18-INK4C
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1031
Uniprot:P42773
Cellular Location:
Calculated MW:15kDa
Observed MW:17KDa
Synonyms:INK4C, p18, p18-INK4C
Background:The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
UniProt Protein Function:Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
NCBI Summary:The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:P42773
NCBI GenInfo Identifier:1168870
NCBI Gene ID:1031
NCBI Accession:P42773.1
UniProt Secondary Accession:P42773,Q8TB83,
UniProt Related Accession:P42773
Molecular Weight:18kDa
NCBI Full Name:Cyclin-dependent kinase 4 inhibitor C
NCBI Synonym Full Names:cyclin dependent kinase inhibitor 2C
NCBI Official Symbol:CDKN2C  
NCBI Official Synonym Symbols:p18; INK4C; p18-INK4C  
NCBI Protein Information:cyclin-dependent kinase 4 inhibitor C
UniProt Protein Name:Cyclin-dependent kinase 4 inhibitor C
UniProt Synonym Protein Names:Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6
Protein Family:Cyclin-dependent kinase 4 inhibitor
UniProt Gene Name:CDKN2C  
Anti-CDKN2C/p18-INK4C Antibody (CAB8751)Western blot - CDKN2C/p18-INK4C Rabbit mAb (CAB8751)
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