Cell Biology Antibodies 7
Anti-CDKL3 Antibody (CAB16689)
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- SKU:
- CAB16689
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CDKL3 Antibody |
| Antibody SKU: | CAB16689 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human CDKL3 (NP_001107047). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, LO2, BxPC-3, mouse brain, mouse spleen, mouse liver, rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human CDKL3 (NP_001107047). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEMY ETLG KVGE GSYG TVMK CKHK NTGQ IVAI KIFY ERPE QSVN KIAM REIK FLKQ FHHE NLVN LIEV FRQK KKIH LVFE FIDH TVLD ELQH YCHG LESK RLRK YLFQ ILRA IDYL HSNN |
| Gene ID: | 51265 |
| Uniprot: | Q8IVW4 |
| Cellular Location: | |
| Calculated MW: | 68kDa |
| Observed MW: | 52kDa/75kDa |
| Synonyms: | CDKL3, NKIAMRE |
| Background: | The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | CDKL3: a protein kinase of the CDKL family. Absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. The function of this gene has not yet been determined. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Kinase, protein; Protein kinase, CMGC; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDKL family Chromosomal Location of Human Ortholog: 5q31 Molecular Function:protein binding; protein kinase activity Biological Process: protein modification process |
| NCBI Summary: | The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8IVW4 |
| NCBI GenInfo Identifier: | 74762479 |
| NCBI Gene ID: | 51265 |
| NCBI Accession: | Q8IVW4.1 |
| UniProt Secondary Accession: | Q8IVW4,Q9P114, D3DQA0, D3DQA1, |
| UniProt Related Accession: | Q8IVW4 |
| Molecular Weight: | 51,566 Da |
| NCBI Full Name: | Cyclin-dependent kinase-like 3 |
| NCBI Synonym Full Names: | cyclin dependent kinase like 3 |
| NCBI Official Symbol: | CDKL3 |
| NCBI Official Synonym Symbols: | NKIAMRE |
| NCBI Protein Information: | cyclin-dependent kinase-like 3 |
| UniProt Protein Name: | Cyclin-dependent kinase-like 3 |
| UniProt Synonym Protein Names: | Serine/threonine-protein kinase NKIAMRE |
| Protein Family: | Cyclin-dependent kinase |
| UniProt Gene Name: | CDKL3 |
| UniProt Entry Name: | CDKL3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CDKL3 antibody (CAB16689) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded Human colon carcinoma using CDKL3 Rabbit pAb (CAB16689) at dilution of 1:100 (40x lens). |
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