Immunology Antibodies 1

Anti-CDK13 Antibody (CAB10258)

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SKU:
CAB10258
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-CDK13 Antibody
Antibody SKU:CAB10258
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 620-900 of human CDK13 (NP_003709.3).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human
Positive Samples:U-87MG
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 620-900 of human CDK13 (NP_003709.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KEAD SLRG NISV KAVK KEVE KKLR CLLA DLPL PPEL PGGD DLSK SPEE KKTA TQLH SKRR PKIC GPRY GETK EKDI DWGK RCVD KFDI IGII GEGT YGQV YKAR DKDT GEMV ALKK VRLD NEKE GFPI TAIR EIKI LRQL THQS IINM KEIV TDKE DALD FKKD KGAF YLVF EYMD HDLM GLLE SGLV HFNE NHIK SFMR QLME GLDY CHKK NFLH RDIK CSNI LLNN RGQI KLAD FGLA RLYS SEES RPYT NKVI TLWY RPPE LLLG EERY TPAI DVWS C
Gene ID:8621
Uniprot:Q14004
Cellular Location:Nucleus speckle
Calculated MW:158kDa/164kDa
Observed MW:164kDa
Synonyms:CDK13, CDC2L, CDC2L5, CHDFIDD, CHED, hCDK13
Background:The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.
UniProt Protein Function:CDK13: a CMGC protein kinase of the CDK family. It has been reported to interact with L-type cyclins. Overexpression of CDC2L5 constructs disturbs constitutive splicing and switches alternative splice site selection in vivo suggesting that it may regulate alternative splicing. It has unusually large N- and C-termini and is ubiquitously expressed in many tissues. Two alternatively spliced human isoforms have been described.
UniProt Protein Details:

Protein type:CDK family; CDK/CRK7 subfamily; CMGC group; CRK7 subfamily; Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RNA splicing

Chromosomal Location of Human Ortholog: 7p14.1

Cellular Component: chromosome; cytosol; extracellular region; extracellular space; Golgi apparatus; nuclear cyclin-dependent protein kinase holoenzyme complex; nuclear speck; nucleoplasm; transcription elongation factor complex b

Molecular Function:cyclin binding; cyclin-dependent protein kinase activity; protein binding; protein kinase activity; RNA binding; RNA polymerase subunit kinase activity; transcription factor binding

Biological Process: alternative nuclear mRNA splicing, via spliceosome; hemopoiesis; multicellular organismal development; neutrophil degranulation; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of mitosis; RNA elongation from RNA polymerase II promoter

NCBI Summary:The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009]
UniProt Code:Q14004
NCBI GenInfo Identifier:66774048
NCBI Gene ID:8621
NCBI Accession:Q14004.2
UniProt Secondary Accession:Q14004,Q53G78, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0 Q9H4A1, Q9UDR4,
UniProt Related Accession:Q14004
Molecular Weight:Observed MW: 210kDaCalculated MW: 158kDa/164kDa
NCBI Full Name:Cyclin-dependent kinase 13
NCBI Synonym Full Names:cyclin dependent kinase 13
NCBI Official Symbol:CDK13  
NCBI Official Synonym Symbols:CHED; CDC2L; CDC2L5; hCDK13; CHDFIDD  
NCBI Protein Information:cyclin-dependent kinase 13
UniProt Protein Name:Cyclin-dependent kinase 13
UniProt Synonym Protein Names:CDC2-related protein kinase 5; Cell division cycle 2-like protein kinase 5; Cell division protein kinase 13; hCDK13; Cholinesterase-related cell division controller
Protein Family:Cyclin-dependent kinase
UniProt Gene Name:CDK13  
Anti-CDK13 Antibody (CAB10258)Western blot analysis of extracts of U-87MG cells, using CDK13 antibody (CAB10258) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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