Cell Biology Antibodies 4
Anti-CDH8 Antibody (CAB14236)
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- SKU:
- CAB14236
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CDH8 Antibody |
| Antibody SKU: | CAB14236 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 500-610 of human CDH8 (NP_001787.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-87MG, U-251MG, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 500-610 of human CDH8 (NP_001787.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YEAF LCEN GKPG QVIQ TVSA MDKD DPKN GHYF LYSL LPEM VNNP NFTI KKNE DNSL SILA KHNG FNRQ KQEV YLLP IIIS DSGN PPLS STST LTIR VCGC SNDG VVQS CNV |
| Gene ID: | 1006 |
| Uniprot: | P55286 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 88kDa |
| Observed MW: | 110kDa |
| Synonyms: | CDH8, Nbla04261 |
| Background: | This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. |
| UniProt Protein Function: | CDH8: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: plasma membrane Biological Process: cell adhesion |
| NCBI Summary: | This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P55286 |
| NCBI GenInfo Identifier: | 13432121 |
| NCBI Gene ID: | 1006 |
| NCBI Accession: | P55286.2 |
| UniProt Secondary Accession: | P55286,Q14DC6, Q9ULB2, B3KWC1, |
| UniProt Related Accession: | P55286 |
| Molecular Weight: | 88,253 Da |
| NCBI Full Name: | Cadherin-8 |
| NCBI Synonym Full Names: | cadherin 8 |
| NCBI Official Symbol: | CDH8 |
| NCBI Official Synonym Symbols: | Nbla04261 |
| NCBI Protein Information: | cadherin-8 |
| UniProt Protein Name: | Cadherin-8 |
| Protein Family: | Cadherin |
| UniProt Gene Name: | CDH8 |
| UniProt Entry Name: | CADH8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CDH8 antibody (CAB14236) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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