Cell Biology Antibodies 4
Anti-CDH3 Antibody (CAB14235)
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- SKU:
- CAB14235
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CDH3 Antibody |
| Antibody SKU: | CAB14235 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-350 of human CDH3 (NP_001784.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Rat testis, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-350 of human CDH3 (NP_001784.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SEPC RAVF REAE VTLE AGGA EQEP GQAL GKVF MGCP GQEP ALFS TDND DFTV RNGE TVQE RRSL KERN PLKI FPSK RILR RHKR DWVV APIS VPEN GKGP FPQR LNQL KSNK DRDT KIFY SITG PGAD SPPE GVFA VEKE TGWL LLNK PLDR EEIA KYEL FGHA VSEN GASV EDPM NISI IVTD QNDH KPKF TQDT FRGS VLEG VLPG TSVM QVTA TDED DAIY TYNG VVAY SIHS QEPK DPHD LMFT IHRS TGTI SVIS SGLD REKV PEYT LTIQ ATDM DGDG STTT AVAV VEIL DAND NAPM FDPQ KYEA HVPE NAVG HEVQ RLT |
| Gene ID: | 1001 |
| Uniprot: | P22223 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 86kDa/91kDa |
| Observed MW: | 115kDa |
| Synonyms: | CDH3, CDHP, HJMD, PCAD |
| Background: | This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). |
| UniProt Protein Function: | CDH3: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with CDCP1. Expressed in some normal epithelial tissues and in some carcinoma cell lines. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: cell-cell adherens junction; cytoplasm; integral to membrane; plasma membrane Molecular Function:calcium ion binding Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; response to drug; intercellular junction assembly and maintenance; wound healing; positive regulation of melanin biosynthetic process; Wnt receptor signaling pathway through beta-catenin; negative regulation of transforming growth factor-beta2 production; retinal homeostasis; hair cycle process; cell-cell adhesion; positive regulation of monophenol monooxygenase activity; negative regulation of catagen; visual perception; keratinization; cell adhesion; homophilic cell adhesion Disease: Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome; Hypotrichosis, Congenital, With Juvenile Macular Dystrophy |
| NCBI Summary: | This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P22223 |
| NCBI GenInfo Identifier: | 146345382 |
| NCBI Gene ID: | 1001 |
| NCBI Accession: | P22223.2 |
| UniProt Secondary Accession: | P22223,Q05DI6, B2R6F4, |
| UniProt Related Accession: | P22223 |
| Molecular Weight: | 86,552 Da |
| NCBI Full Name: | Cadherin-3 |
| NCBI Synonym Full Names: | cadherin 3, type 1, P-cadherin (placental) |
| NCBI Official Symbol: | CDH3 |
| NCBI Official Synonym Symbols: | CDHP; HJMD; PCAD |
| NCBI Protein Information: | cadherin-3; calcium-dependent adhesion protein, placental |
| UniProt Protein Name: | Cadherin-3 |
| UniProt Synonym Protein Names: | Placental cadherin; P-cadherin |
| UniProt Gene Name: | CDH3 |
| UniProt Entry Name: | CADH3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CDH3 antibody (CAB14235) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human skin using CDH3 antibody (CAB14235) at dilution of 1:100 (40x lens). |
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