Antibody Name:	Anti-CDH18 Antibody
Antibody SKU:	CAB14645
Antibody Size:	20uL, 50uL, 100uL
Application:	IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 300-500 of human CDH18 (NP_004925.1).

Application:	IHC
Recommended Dilution:	IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 300-500 of human CDH18 (NP_004925.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	NADM TYSI INGD GMGI FSIS TDKE TREG ILSL KKPL NYEK KKSY TLNI EGAN THLD FRFS HLGP FKDA TMLK IIVG DVDE PPLF SMPS YLME VYEN AKIG TVVG TVLA QDPD STNS LVRY FINY NVED DRFF NIDA NTGT IRTT KVLD REET PWYN ITVT ASEI DNPD LLSH VTVG IRVL DVND NPPE LARE YDII VCEN S
Gene ID:	1016
Uniprot:	Q13634
Cellular Location:	Cell membrane, Single-pass type I membrane protein
Calculated MW:	63kDa/88kDa
Observed MW:

Synonyms:

CDH18, CDH14, CDH14L, CDH24

Background:

This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	CDH18: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 5p14.3 Cellular Component: integral to membrane; plasma membrane Molecular Function:calcium ion binding Biological Process: intercellular junction assembly and maintenance; homophilic cell adhesion
NCBI Summary:	This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
UniProt Code:	Q13634
NCBI GenInfo Identifier:	4826671
NCBI Gene ID:	1016
NCBI Accession:	NP_004925.1
UniProt Secondary Accession:	Q13634,Q8N5Z2, A8K0I2, B4DHG6,
UniProt Related Accession:	Q13634
Molecular Weight:	63,677 Da
NCBI Full Name:	cadherin-18 isoform 1 preproprotein
NCBI Synonym Full Names:	cadherin 18, type 2
NCBI Official Symbol:	CDH18
NCBI Official Synonym Symbols:	CDH14; CDH24; CDH14L
NCBI Protein Information:	cadherin-18; cadherin-14; ey-cadherin; cadherin-like 24
UniProt Protein Name:	Cadherin-18
UniProt Synonym Protein Names:	Cadherin-14
Protein Family:	Cadherin
UniProt Gene Name:	CDH18
UniProt Entry Name:	CAD18_HUMAN

	Immunohistochemistry of paraffin-embedded rat brain using CDH18 antibody (CAB14645) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse liver using CDH18 antibody (CAB14645) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse brain using CDH18 antibody (CAB14645) at dilution of 1:100 (40x lens).