Cell Biology Antibodies 10

Anti-CDH17 Antibody (CAB6555)

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SKU:
CAB6555
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-CDH17 Antibody
Antibody SKU:CAB6555
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human CDH17
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:SGC-7901, HT-29, Mouse spleen, Mouse liver
Immunogen:Recombinant protein of human CDH17
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1015
Uniprot:Q12864
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:92kDa
Observed MW:120kDa
Synonyms:CDH17, CDH16, HPT-1, HPT1
Background:This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:CDH17: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: basolateral plasma membrane; plasma membrane; integral to membrane

Molecular Function:transporter activity; calcium ion binding; proton-dependent oligopeptide secondary active transmembrane transporter activity

Biological Process: intercellular junction assembly and maintenance; transport; calcium-dependent cell-cell adhesion; cell adhesion; oligopeptide transport; homophilic cell adhesion

NCBI Summary:This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
UniProt Code:Q12864
NCBI GenInfo Identifier:308153624
NCBI Gene ID:1015
NCBI Accession:Q12864.3
UniProt Secondary Accession:Q12864,Q15336, Q2M2E0,
UniProt Related Accession:Q12864
Molecular Weight:92,219 Da
NCBI Full Name:Cadherin-17
NCBI Synonym Full Names:cadherin 17, LI cadherin (liver-intestine)
NCBI Official Symbol:CDH17  
NCBI Official Synonym Symbols:HPT1; CDH16; HPT-1  
NCBI Protein Information:cadherin-17; LI cadherin; LI-cadherin; cadherin-16; HPT-1 cadherin; liver-intestine cadherin; human peptide transporter 1; intestinal peptide-associated transporter HPT-1; human intestinal peptide-associated transporter HPT-1
UniProt Protein Name:Cadherin-17
UniProt Synonym Protein Names:Intestinal peptide-associated transporter HPT-1; Liver-intestine cadherin; LI-cadherin
Protein Family:Cadherin
UniProt Gene Name:CDH17  
UniProt Entry Name:CAD17_HUMAN
Anti-CDH17 Antibody (CAB6555)Western blot analysis of extracts of various cell lines, using CDH17 antibody (CAB6555) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 10s.
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