Cell Biology Antibodies 10
Anti-CDH17 Antibody (CAB6555)
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- SKU:
- CAB6555
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CDH17 Antibody |
| Antibody SKU: | CAB6555 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human CDH17 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SGC-7901, HT-29, Mouse spleen, Mouse liver |
| Immunogen: | Recombinant protein of human CDH17 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1015 |
| Uniprot: | Q12864 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 92kDa |
| Observed MW: | 120kDa |
| Synonyms: | CDH17, CDH16, HPT-1, HPT1 |
| Background: | This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CDH17: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 8q22.1 Cellular Component: basolateral plasma membrane; plasma membrane; integral to membrane Molecular Function:transporter activity; calcium ion binding; proton-dependent oligopeptide secondary active transmembrane transporter activity Biological Process: intercellular junction assembly and maintenance; transport; calcium-dependent cell-cell adhesion; cell adhesion; oligopeptide transport; homophilic cell adhesion |
| NCBI Summary: | This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009] |
| UniProt Code: | Q12864 |
| NCBI GenInfo Identifier: | 308153624 |
| NCBI Gene ID: | 1015 |
| NCBI Accession: | Q12864.3 |
| UniProt Secondary Accession: | Q12864,Q15336, Q2M2E0, |
| UniProt Related Accession: | Q12864 |
| Molecular Weight: | 92,219 Da |
| NCBI Full Name: | Cadherin-17 |
| NCBI Synonym Full Names: | cadherin 17, LI cadherin (liver-intestine) |
| NCBI Official Symbol: | CDH17 |
| NCBI Official Synonym Symbols: | HPT1; CDH16; HPT-1 |
| NCBI Protein Information: | cadherin-17; LI cadherin; LI-cadherin; cadherin-16; HPT-1 cadherin; liver-intestine cadherin; human peptide transporter 1; intestinal peptide-associated transporter HPT-1; human intestinal peptide-associated transporter HPT-1 |
| UniProt Protein Name: | Cadherin-17 |
| UniProt Synonym Protein Names: | Intestinal peptide-associated transporter HPT-1; Liver-intestine cadherin; LI-cadherin |
| Protein Family: | Cadherin |
| UniProt Gene Name: | CDH17 |
| UniProt Entry Name: | CAD17_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CDH17 antibody (CAB6555) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 10s. |
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