Anti-CDH15 Antibody (CAB13795)
- SKU:
- CAB13795
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CDH15
- Synonyms:
- CDH14
- Synonyms:
- CDH3
- Synonyms:
- CDHM
- Synonyms:
- MCAD
- Synonyms:
- MRD3
- Research Area:
- Cell Biology
Description
| Product Name: | CDH15 Rabbit pAb |
| Product Code: | CAB13795 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CDH15, CDH14, CDH3, CDHM, MCAD, MRD3 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human CDH15 (NP_004924.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG, HT-1080 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human CDH15 (NP_004924.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AAAL RAER GQAK VRVH VQDT NEPP VFQE NPLR TSLA EGAP PGTL VATF SARD PDTE QLQR LSYS KDYD PEDW LQVD AATG RIQT QHVL SPAS PFLK GGWY R |
| Gene ID: | 1013 |
| Uniprot: | P55291 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 88kDa |
| Observed MW: | 89kDa |
| UniProt Protein Function: | CDH15: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation. A chromosomal aberration involving CDH15 and KIRREL3 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24). Defects in CDH15 are the cause of mental retardation autosomal dominant type 3 (MRD3). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 16q24.3 Cellular Component: plasma membrane; integral to membrane; caveola; neuromuscular junction Molecular Function:calcium ion binding Biological Process: intercellular junction assembly and maintenance; muscle cell differentiation; positive regulation of muscle cell differentiation; homophilic cell adhesion; cell adhesion Disease: Mental Retardation, Autosomal Dominant 3 |
| NCBI Summary: | This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P55291 |
| NCBI GenInfo Identifier: | 1705553 |
| NCBI Gene ID: | 1013 |
| NCBI Accession: | P55291.1 |
| UniProt Related Accession: | P55291 |
| Molecular Weight: | 88,916 Da |
| NCBI Full Name: | Cadherin-15 |
| NCBI Synonym Full Names: | cadherin 15, type 1, M-cadherin (myotubule) |
| NCBI Official Symbol: | CDH15 |
| NCBI Official Synonym Symbols: | CDH3; CDHM; MCAD; MRD3; CDH14 |
| NCBI Protein Information: | cadherin-15; cadherin-3; cadherin-14; muscle-cadherin |
| UniProt Protein Name: | Cadherin-15 |
| UniProt Synonym Protein Names: | Cadherin-14; Muscle cadherin; M-cadherin |
| Protein Family: | Cadherin |
| UniProt Gene Name: | CDH15 |
| UniProt Entry Name: | CAD15_HUMAN |
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