Cell Biology Antibodies 4

Anti-CDH15 Antibody (CAB13794)

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SKU:
CAB13794
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CDH15 Antibody
Antibody SKU:CAB13794
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 350-450 of human CDH15 (NP_004924.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:Rat brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 350-450 of human CDH15 (NP_004924.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AAAL RAER GQAK VRVH VQDT NEPP VFQE NPLR TSLA EGAP PGTL VATF SARD PDTE QLQR LSYS KDYD PEDW LQVD AATG RIQT QHVL SPAS PFLK GGWY R
Gene ID:1013
Uniprot:P55291
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:88kDa
Observed MW:89kDa
Synonyms:CDH15, CDH14, CDH3, CDHM, MCAD, MRD3
Background:This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.
UniProt Protein Function:CDH15: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation. A chromosomal aberration involving CDH15 and KIRREL3 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24). Defects in CDH15 are the cause of mental retardation autosomal dominant type 3 (MRD3). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 16q24.3

Cellular Component: plasma membrane; integral to membrane; caveola; neuromuscular junction

Molecular Function:calcium ion binding

Biological Process: intercellular junction assembly and maintenance; muscle cell differentiation; positive regulation of muscle cell differentiation; homophilic cell adhesion; cell adhesion

Disease: Mental Retardation, Autosomal Dominant 3

NCBI Summary:This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008]
UniProt Code:P55291
NCBI GenInfo Identifier:1705553
NCBI Gene ID:1013
NCBI Accession:P55291.1
UniProt Related Accession:P55291
Molecular Weight:88,916 Da
NCBI Full Name:Cadherin-15
NCBI Synonym Full Names:cadherin 15, type 1, M-cadherin (myotubule)
NCBI Official Symbol:CDH15  
NCBI Official Synonym Symbols:CDH3; CDHM; MCAD; MRD3; CDH14  
NCBI Protein Information:cadherin-15; cadherin-3; cadherin-14; muscle-cadherin
UniProt Protein Name:Cadherin-15
UniProt Synonym Protein Names:Cadherin-14; Muscle cadherin; M-cadherin
Protein Family:Cadherin
UniProt Gene Name:CDH15  
UniProt Entry Name:CAD15_HUMAN
Anti-CDH15 Antibody (CAB13794)Western blot analysis of extracts of rat brain, using CDH15 antibody (CAB13794) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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