Cell Biology Antibodies 2
Anti-CDH11 Antibody (CAB12176)
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- SKU:
- CAB12176
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CDH11 Antibody |
| Antibody SKU: | CAB12176 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human CDH11 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG, A-549, HT-29 |
| Immunogen: | Recombinant protein of human CDH11 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1009 |
| Uniprot: | P55287 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 76kDa/87kDa |
| Observed MW: | 110kDa |
| Synonyms: | CDH11, CAD11, CDHOB, OB, OSF-4 |
| Background: | This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. |
| UniProt Protein Function: | CDH11: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with PCDH8. Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 16q21 Cellular Component: cytoplasm; integral to membrane; plasma membrane Molecular Function:calcium ion binding Biological Process: intercellular junction assembly and maintenance; ossification; corticospinal tract morphogenesis; homophilic cell adhesion; cell adhesion; skeletal development |
| UniProt Code: | P55287 |
| NCBI GenInfo Identifier: | 16306532 |
| NCBI Gene ID: | 1009 |
| NCBI Accession: | NP_001788 |
| UniProt Secondary Accession: | P55287,Q15065, Q15066, Q9UQ93, Q9UQ94, A8K5D6, A8MZC8 B7WP28, |
| UniProt Related Accession: | P55287 |
| Molecular Weight: | 76,457 Da |
| NCBI Full Name: | cadherin-11 preproprotein |
| NCBI Synonym Full Names: | cadherin 11, type 2, OB-cadherin (osteoblast) |
| NCBI Official Symbol: | CDH11 |
| NCBI Official Synonym Symbols: | OB; CAD11; CDHOB; OSF-4 |
| NCBI Protein Information: | cadherin-11 |
| UniProt Protein Name: | Cadherin-11 |
| UniProt Synonym Protein Names: | OSF-4; Osteoblast cadherin |
| Protein Family: | Cadherin |
| UniProt Gene Name: | CDH11 |
| UniProt Entry Name: | CAD11_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CDH11 antibody (CAB12176) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
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