Cell Biology Antibodies 1

Anti-CDH10 Antibody (CAB10204)

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SKU:
CAB10204
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CDH10 Antibody
Antibody SKU:CAB10204
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-260 of human CDH10 (NP_006718.2).
Application:WB IF
Recommended Dilution:WB 1:1000 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-260 of human CDH10 (NP_006718.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CSPE IMFR RTPV PQQR ILSS RVPR SDGK ILHR QKRG WMWN QFFL LEEY TGSD YQYV GKLH SDQD KGDG SLKY ILSG DGAG TLFI IDEK TGDI HATR RIDR EEKA FYTL RAQA INRR TLRP VEPE SEFV IKIH DIND NEPT FPEE IYTA SVPE MSVV GTSV VQVT ATDA DDPS YGNS ARVI YSIL QGQP YFSV EPET GIIR TALP NMNR ENRE QYQV VIQA KDMG GQMG GLSG TTTV NITL T
Gene ID:1008
Uniprot:Q9Y6N8
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:88kDa
Observed MW:105kDa
Synonyms:CDH10
Background:This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients.
UniProt Protein Function:CDH10: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
UniProt Protein Details:

Protein type:Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5p14.2

Cellular Component: plasma membrane

NCBI Summary:This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients. [provided by RefSeq, Nov 2015]
UniProt Code:Q9Y6N8
NCBI GenInfo Identifier:116241276
NCBI Gene ID:1008
NCBI Accession:Q9Y6N8.2
UniProt Secondary Accession:Q9Y6N8,Q9ULB3,
UniProt Related Accession:Q9Y6N8
Molecular Weight:88,451 Da
NCBI Full Name:Cadherin-10
NCBI Synonym Full Names:cadherin 10
NCBI Official Symbol:CDH10  
NCBI Protein Information:cadherin-10
UniProt Protein Name:Cadherin-10
UniProt Synonym Protein Names:T2-cadherin
Protein Family:Cadherin
UniProt Gene Name:CDH10  
UniProt Entry Name:CAD10_HUMAN
Anti-CDH10 Antibody (CAB10204)Western blot analysis of extracts of various cell lines, using CDH10 antibody (CAB10204) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Basic Kit (RM00020)._Exposure time: 10s.
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