Cell Cycle Antibodies 2

Anti-CDC5L Antibody (CAB9527)

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SKU:
CAB9527
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-CDC5L Antibody
Antibody SKU:CAB9527
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CDC5L
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HeLa, 293T, SH-SY5Y, Mouse testis, Mouse brain, Mouse thymus
Immunogen:A synthesized peptide derived from human CDC5L
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:988
Uniprot:Q99459
Cellular Location:
Calculated MW:100kDa
Observed MW:100KDa
Synonyms:CDC5, CDC5-LIKE, CEF1, PCDC5RP, dJ319D22.1
Background:The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]
UniProt Protein Function:CDC5L: is a spliceosome protein that binds DNA and that also regulates transcription. Is a positive regulator of cell cycle G2/M progression. Is an essential component of non-snRNA spliceosomes and is required for the second catalytic step of pre-mRNA splicing. Binds adeno-pre-mRNA in an ATP-stimulated manner. Is part of a spliceosomal 'core' complex that includes CDC5L, SF2, PRLI, SPF27, HSP7C, PRPF19/SNEV, GCN1L. Identified in the spliceosome C complex. Has been associated with aneuploidy in aging cells and in tumorigenesis. The genomic region containing the gene for CDC5L (6p21.1) is frequently amplified in osteosarcomas.
UniProt Protein Details:

Protein type:DNA-binding; RNA processing; Transcription factor; Spliceosome; Motility/polarity/chemotaxis; RNA splicing

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: nucleoplasm; DNA replication factor A complex; membrane; cytoplasm; nucleolus; nuclear speck; nucleus

Molecular Function:protein binding; DNA binding; chromatin binding

Biological Process: nuclear mRNA splicing, via spliceosome; transcription, DNA-dependent; regulation of transcription, DNA-dependent; RNA splicing; gene expression; DNA repair

NCBI Summary:The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]
UniProt Code:Q99459
NCBI GenInfo Identifier:73619933
NCBI Gene ID:988
NCBI Accession:Q99459.2
UniProt Related Accession:Q99459
Molecular Weight:100kDa
NCBI Full Name:Cell division cycle 5-like protein
NCBI Synonym Full Names:cell division cycle 5 like
NCBI Official Symbol:CDC5L  
NCBI Official Synonym Symbols:CDC5; CEF1; PCDC5RP; CDC5-LIKE; dJ319D22.1  
NCBI Protein Information:cell division cycle 5-like protein
UniProt Protein Name:Cell division cycle 5-like protein
UniProt Synonym Protein Names:Pombe cdc5-related protein
Protein Family:CDC50 family protein
UniProt Gene Name:CDC5L  
UniProt Entry Name:CDC5L_HUMAN
Anti-CDC5L Antibody (CAB9527)Western blot - CDC5L Rabbit mAb (CAB9527)
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