Anti-CDC27 Antibody (CAB3333)
- SKU:
- CAB3333
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ANAPC3
- Synonyms:
- APC3
- Synonyms:
- CDC27Hs
- Synonyms:
- D0S1430E
- Synonyms:
- D17S978E
- Synonyms:
- H-NUC
- Synonyms:
- HNUC
- Synonyms:
- NUC2
Description
| Product Name: | CDC27 Rabbit mAb |
| Product Code: | CAB3333 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ANAPC3, APC3, CDC27Hs, D0S1430E, D17S978E, H-NUC, HNUC, NUC2 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CDC27 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | DU145, Mouse testis, Rat testis |
| Immunogen: | A synthesized peptide derived from human CDC27 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 996 |
| Uniprot: | P30260 |
| Cellular Location: | Nucleus |
| Calculated MW: | 91kDa |
| Observed MW: | 100kDa |
| UniProt Protein Function: | CDC27: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C is composed of at least 12 subunits. Interacts with RB. Interacts with FAM168B/MANI. Belongs to the APC3/CDC27 family. |
| UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 17q21.32 Cellular Component: nucleoplasm; centrosome; anaphase-promoting complex; spindle microtubule; cytoplasm; spindle; cytosol; nucleus Molecular Function:protein binding; protein phosphatase binding Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell proliferation; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle; mitotic metaphase/anaphase transition |
| NCBI Summary: | The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014] |
| UniProt Code: | P30260 |
| NCBI GenInfo Identifier: | 12644198 |
| NCBI Gene ID: | 996 |
| NCBI Accession: | P30260.2 |
| UniProt Secondary Accession: | P30260,Q16349, Q96F35, G3V1C4, |
| UniProt Related Accession: | P30260 |
| Molecular Weight: | 824 |
| NCBI Full Name: | Cell division cycle protein 27 homolog |
| NCBI Synonym Full Names: | cell division cycle 27 |
| NCBI Official Symbol: | CDC27 |
| NCBI Official Synonym Symbols: | APC3; HNUC; NUC2; H-NUC; ANAPC3; CDC27Hs; D0S1430E; D17S978E |
| NCBI Protein Information: | cell division cycle protein 27 homolog; nuc2 homolog; cell division cycle 27 homolog; anaphase promoting complex subunit 3; anaphase-promoting complex, protein 3 |
| UniProt Protein Name: | Cell division cycle protein 27 homolog |
| UniProt Synonym Protein Names: | Anaphase-promoting complex subunit 3; APC3; CDC27 homolog; CDC27Hs; H-NUC |
| Protein Family: | Cell division cycle protein |
| UniProt Gene Name: | CDC27 |
| UniProt Entry Name: | CDC27_HUMAN |
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