Anti-Cdc25C Antibody (CAB12234)
- SKU:
- CAB12234
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CDC25
- Synonyms:
- PPP1R60
- Research Area:
- Cell Cycle
Description
| Product Name: | Cdc25C Rabbit mAb |
| Product Code: | CAB12234 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CDC25, PPP1R60 |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Cdc25C |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Mouse liver, Rat liver |
| Immunogen: | A synthesized peptide derived from human Cdc25C |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 995 |
| Uniprot: | P30307 |
| Calculated MW: | 60kDa |
| Observed MW: | 60-65KDa |
| UniProt Protein Function: | CDC25C: a member of the MPI phosphatase family. Activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. Shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. At least four transcript variants for this gene exist. Three splice variant isoforms have been described. |
| UniProt Protein Details: | Protein type:EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity Chromosomal Location of Human Ortholog: 5q31 Cellular Component: cytosol; nucleoplasm; nucleus Molecular Function:phosphoprotein phosphatase activity; protein binding; protein kinase binding; WW domain binding Biological Process: cell proliferation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA replication; G2/M transition of mitotic cell cycle; regulation of cell cycle; regulation of cyclin-dependent protein kinase activity; regulation of mitosis |
| NCBI Summary: | This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015] |
| UniProt Code: | P30307 |
| NCBI GenInfo Identifier: | 116242631 |
| NCBI Gene ID: | 995 |
| NCBI Accession: | P30307.2 |
| UniProt Secondary Accession: | P30307,Q96PL3, Q9H168, Q9H2E8, Q9H2E9, Q9H2F1, D3DQB8 |
| UniProt Related Accession: | P30307 |
| Molecular Weight: | 45,608 Da |
| NCBI Full Name: | M-phase inducer phosphatase 3 |
| NCBI Synonym Full Names: | cell division cycle 25C |
| NCBI Official Symbol: | CDC25C |
| NCBI Official Synonym Symbols: | CDC25; PPP1R60 |
| NCBI Protein Information: | M-phase inducer phosphatase 3 |
| UniProt Protein Name: | M-phase inducer phosphatase 3 |
| UniProt Synonym Protein Names: | Dual specificity phosphatase Cdc25C |
| UniProt Gene Name: | CDC25C |
| UniProt Entry Name: | MPIP3_HUMAN |
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