Anti-CDC16 Antibody (CAB3583)
- SKU:
- CAB3583
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ANAPC6
- Synonyms:
- APC6
- Synonyms:
- CDC16Hs
- Synonyms:
- CUT9
- Research Area:
- Cell Cycle
Description
| Product Name: | CDC16 Rabbit mAb |
| Product Code: | CAB3583 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ANAPC6, APC6, CDC16Hs, CUT9 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CDC16 |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NIH/3T3 |
| Immunogen: | A synthesized peptide derived from human CDC16 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8881 |
| Uniprot: | Q13042 |
| Cellular Location: | Cytoplasm, centrosome, cytoskeleton, microtubule organizing center, spindle |
| Calculated MW: | 72kDa |
| Observed MW: | 72kDa |
| UniProt Protein Function: | CDC16: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C is composed of at least 12 subunits. Interacts with PPP5C and CDC20. Belongs to the APC6/CDC16 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 13q34 Cellular Component: nucleoplasm; centrosome; anaphase-promoting complex; spindle microtubule; cytoplasm; spindle; cytosol Molecular Function:protein binding Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell proliferation; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; regulation of mitosis; mitotic cell cycle |
| NCBI Summary: | This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13042 |
| NCBI GenInfo Identifier: | 37537763 |
| NCBI Gene ID: | 8881 |
| NCBI Accession: | Q13042.2 |
| UniProt Secondary Accession: | Q13042,Q5T8C8, Q7Z651, Q96AE6, Q9Y564, A2A365, |
| UniProt Related Accession: | Q13042 |
| Molecular Weight: | 620 |
| NCBI Full Name: | Cell division cycle protein 16 homolog |
| NCBI Synonym Full Names: | cell division cycle 16 |
| NCBI Official Symbol: | CDC16 |
| NCBI Official Synonym Symbols: | APC6; CUT9; ANAPC6 |
| NCBI Protein Information: | cell division cycle protein 16 homolog; CDC16Hs; cyclosome subunit 6; cell division cycle 16 homolog; anaphase-promoting complex subunit 6; anaphase-promoting complex, subunit 6 |
| UniProt Protein Name: | Cell division cycle protein 16 homolog |
| UniProt Synonym Protein Names: | Anaphase-promoting complex subunit 6; APC6; CDC16 homolog; CDC16Hs; Cyclosome subunit 6 |
| Protein Family: | Cell division control protein |
| UniProt Gene Name: | CDC16 |
| UniProt Entry Name: | CDC16_HUMAN |
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