Cell Biology Antibodies 13

Anti-CDC14A Antibody (CAB17568)

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SKU:
CAB17568
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CDC14A Antibody
Antibody SKU:CAB17568
Antibody Size:20uL, 50 uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 180-260 of human CDC14A (NP_201569.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 180-260 of human CDC14A (NP_201569.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FNWI VPGK FLAF SGPH PKSK IENG YPLH APEA YFPY FKKH NVTA VVRL NKKI YEAK RFTD AGFE HYDL FFID GSTP SDNI V
Gene ID:8556
Uniprot:Q9UNH5
Cellular Location:
Calculated MW:22kDa/43kDa/66kDa/68kDa/69kDa
Observed MW:Refer to figures
Synonyms:CDC14A, DFNB105, cdc14, hCDC14
Background:The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
UniProt Protein Function:CDC14A: Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC- FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.1.3.48; EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 1p21

Cellular Component: nucleoplasm; centrosome; cytoplasm; spindle; nucleus

Molecular Function:protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; phosphoprotein phosphatase activity

Biological Process: cell proliferation; cell division; cell cycle

NCBI Summary:The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UNH5
NCBI GenInfo Identifier:55976620
NCBI Gene ID:8556
NCBI Accession:Q9UNH5.1
UniProt Secondary Accession:Q9UNH5,O43171, O60727, O60728, Q52LH9, Q8IXX0, A6MA65 B1AQ14, B1AQ15,
UniProt Related Accession:Q9UNH5
Molecular Weight:594
NCBI Full Name:Dual specificity protein phosphatase CDC14A
NCBI Synonym Full Names:cell division cycle 14A
NCBI Official Symbol:CDC14A  
NCBI Official Synonym Symbols:cdc14; hCDC14  
NCBI Protein Information:dual specificity protein phosphatase CDC14A; CDC14 cell division cycle 14 homolog A; CDC10 (cell division cycle 10, S. cerevisiae, homolog)
UniProt Protein Name:Dual specificity protein phosphatase CDC14A
UniProt Synonym Protein Names:CDC14 cell division cycle 14 homolog A
Protein Family:Dual specificity protein phosphatase
UniProt Gene Name:CDC14A  
UniProt Entry Name:CC14A_HUMAN
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