Cell Biology Antibodies 15

Anti-CDAN1 Antibody (CAB17833)

(No reviews yet) Write a Review
SKU:
CAB17833
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-CDAN1 Antibody
Antibody SKU:CAB17833
Antibody Size:20uL, 50 uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide of Human CDAN1.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:A synthetic peptide of Human CDAN1.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:146059
Uniprot:Q8IWY9
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:CDA1, CDAI, CDAN1A, DLT, PRO1295, CDAN1
Background:This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. [provided by RefSeq, Jul 2009]
UniProt Protein Function:CDAN1: Might be involved in nuclear membrane integrity. Defects in CDAN1 are the cause of congenital dyserythropoietic anemia type 1 (CDA1). An autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis. It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis. Ultrastructural features include internuclear chromatin bridges connecting some nearly completely separated erythroblasts and an abnormal appearance (spongy or Swiss-cheese appearance) of the heterochromatin in a high proportion of the erythroblasts. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q15.2

Cellular Component: cytoplasm; plasma membrane; integral to membrane; endomembrane system; nucleus

Molecular Function:protein binding

Biological Process: protein localization; establishment and/or maintenance of chromatin architecture; negative regulation of DNA replication; chromatin assembly

Disease: Anemia, Congenital Dyserythropoietic, Type Ia

NCBI Summary:This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. [provided by RefSeq, Jul 2009]
UniProt Code:Q8IWY9
NCBI GenInfo Identifier:57222570
NCBI Gene ID:146059
NCBI Accession:NP_612486.2
UniProt Secondary Accession:Q8IWY9,Q6NYD0, Q7Z7L5, Q969N3,
UniProt Related Accession:Q8IWY9
Molecular Weight:Calculated MW: 134kDaObserved MW: 130kDa
NCBI Full Name:codanin-1
NCBI Synonym Full Names:codanin 1
NCBI Official Symbol:CDAN1  
NCBI Official Synonym Symbols:DLT; CDA1; CDAI; CDAN1A; PRO1295  
NCBI Protein Information:codanin-1; congenital dyserythropoietic anemia, type I; discs lost homolog
UniProt Protein Name:Codanin-1
Protein Family:Codanin
UniProt Gene Name:CDAN1  
UniProt Entry Name:CDAN1_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products