Cell Biology Antibodies 4
Anti-CDA Antibody (CAB13959)
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- SKU:
- CAB13959
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CDA Antibody |
| Antibody SKU: | CAB13959 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-146 of human CDA (NP_001776.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, HepG2, 293T, Jurkat, SW620, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-146 of human CDA (NP_001776.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAQK RPAC TLKP ECVQ QLLV CSQE AKKS AYCP YSHF PVGA ALLT QEGR IFKG CNIE NACY PLGI CAER TAIQ KAVS EGYK DFRA IAIA SDMQ DDFI SPCG ACRQ VMRE FGTN WPVY MTKP DGTY IVMT VQEL LPSS FGPE DLQK TQ |
| Gene ID: | 978 |
| Uniprot: | P32320 |
| Cellular Location: | |
| Calculated MW: | 16kDa |
| Observed MW: | 15kDa, 35kDa, 65kDa |
| Synonyms: | CDA, CDD |
| Background: | This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. |
| UniProt Protein Function: | CDA: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Belongs to the cytidine and deoxycytidylate deaminase family. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - pyrimidine; Hydrolase; Xenobiotic Metabolism - drug metabolism - other enzymes; EC 3.5.4.5 Chromosomal Location of Human Ortholog: 1p36.2-p35 Cellular Component: extracellular region; cytosol Molecular Function:protein homodimerization activity; zinc ion binding; nucleoside binding; cytidine deaminase activity Biological Process: cell surface receptor linked signal transduction; pyrimidine base metabolic process; cytosine metabolic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleoside salvage; cytidine deamination; negative regulation of cell growth; pyrimidine salvage; negative regulation of nucleotide metabolic process; protein homotetramerization |
| NCBI Summary: | This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P32320 |
| NCBI GenInfo Identifier: | 1705718 |
| NCBI Gene ID: | 978 |
| NCBI Accession: | P32320.2 |
| UniProt Related Accession: | P32320 |
| Molecular Weight: | |
| NCBI Full Name: | Cytidine deaminase |
| NCBI Synonym Full Names: | cytidine deaminase |
| NCBI Official Symbol: | CDA |
| NCBI Official Synonym Symbols: | CDD |
| NCBI Protein Information: | cytidine deaminase |
| UniProt Protein Name: | Cytidine deaminase |
| UniProt Synonym Protein Names: | Cytidine aminohydrolase |
| Protein Family: | Colicin |
| UniProt Gene Name: | CDA |
| UniProt Entry Name: | CDD_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CDA antibody (CAB13959) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using CDA Antibody (CAB13959) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of HeLa cells using CDA antibody (CAB13959). Blue: DAPI for nuclear staining. |
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