Anti-CD84 Antibody (CAB2299)

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SKU:
CAB2299
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CD84
Synonyms:
LY9B
Synonyms:
SLAMF5
Synonyms:
hCD84
Synonyms:
mCD84
Synonyms:
CD84 molecule
Research Area:
Immunology

Description

Product Name:CD84 Rabbit mAb
Product Code:CAB2299
Size:20uL, 50uL, 100uL
Synonyms:CD84, LY9B, SLAMF5, hCD84, mCD84, CD84 molecule
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CD84.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, K-562, Mouse spinal cord, Mouse spleen, Mouse thymus, Rat spinal cord
Immunogen:A synthesized peptide derived from human CD84.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8832
Uniprot:Q9UIB8
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:60-85kDa
Observed MW:55-82KDa
UniProt Protein Function:CD84: Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain- containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells. 7 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Immunoglobulin superfamily; Motility/polarity/chemotaxis; Cell surface

Chromosomal Location of Human Ortholog: 1q24

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:protein binding

Biological Process: adaptive immune response; blood coagulation; defense response; homophilic cell adhesion; innate immune response; leukocyte migration; negative regulation of granulocyte macrophage colony-stimulating factor production; negative regulation of interleukin-18 production; negative regulation of mast cell activation; negative regulation of mast cell degranulation

NCBI Summary:This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
UniProt Code:Q9UIB8
NCBI GenInfo Identifier:74762772
NCBI Gene ID:8832
NCBI Accession:Q9UIB8.1
UniProt Secondary Accession:Q9UIB8,O15430, O95266, O95660, Q5H9R1, Q6FHA8, Q8WLP1 Q8WWI8, Q9UF04, Q9UIB6, B2R8T1, B7Z3R8,
UniProt Related Accession:Q9UIB8
Molecular Weight:24,025 Da
NCBI Full Name:SLAM family member 5
NCBI Synonym Full Names:CD84 molecule
NCBI Official Symbol:CD84  
NCBI Official Synonym Symbols:LY9B; hCD84; mCD84; SLAMF5  
NCBI Protein Information:SLAM family member 5
UniProt Protein Name:SLAM family member 5
UniProt Synonym Protein Names:Cell surface antigen MAX.3; Hly9-beta; Leukocyte differentiation antigen CD84; Signaling lymphocytic activation molecule 5; CD_antigen: CD84
Protein Family:SLAM family
UniProt Gene Name:CD84  
UniProt Entry Name:SLAF5_HUMAN
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