Cell Biology Antibodies 8

Anti-CD83 Antibody (CAB2040)

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SKU:
CAB2040
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CD83 Antibody
Antibody SKU:CAB2040
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-144 of human CD83 (NP_004224.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, Mouse intestine
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-144 of human CD83 (NP_004224.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TPEV KVAC SEDV DLPC TAPW DPQV PYTV SWVK LLEG GEER METP QEDH LRGQ HYHQ KGQN GSFD APNE RPYS LKIR NTTS CNSG TYRC TLQD PDGQ RNLS GKVI LRVT GCPA QRKE ETFK KYRA E
Gene ID:9308
Uniprot:Q01151
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:23kDa
Observed MW:44kDa
Synonyms:CD83, BL11, HB15
Background:The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:CD83: May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p23

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Biological Process: negative regulation of interleukin-4 production; positive regulation of interleukin-2 production; defense response; positive regulation of CD4-positive, alpha beta T cell differentiation; signal transduction; response to organic cyclic substance; positive regulation of interleukin-10 production; humoral immune response

NCBI Summary:The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Code:Q01151
NCBI GenInfo Identifier:232223
NCBI Gene ID:9308
NCBI Accession:Q01151.1
UniProt Secondary Accession:Q01151,Q5THX9,
UniProt Related Accession:Q01151
Molecular Weight:205
NCBI Full Name:CD83 antigen
NCBI Synonym Full Names:CD83 molecule
NCBI Official Symbol:CD83  
NCBI Official Synonym Symbols:BL11; HB15  
NCBI Protein Information:CD83 antigen; hCD83; B-cell activation protein; cell surface protein HB15; cell-surface glycoprotein; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily)
UniProt Protein Name:CD83 antigen
UniProt Synonym Protein Names:B-cell activation protein; Cell surface protein HB15; CD_antigen: CD83
Protein Family:CD83 antigen
UniProt Gene Name:CD83  
UniProt Entry Name:CD83_HUMAN
Anti-CD83 Antibody (CAB2040)Western blot analysis of extracts of various cell lines, using CD83 antibody (CAB2040) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-CD83 Antibody (CAB2040)Immunohistochemistry of paraffin-embedded rat kidney using CD83 antibody (CAB2040) at dilution of 1:200 (40x lens).
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