Cell Biology Antibodies 17

Anti-CD82 Antibody (CAB9264)

(No reviews yet) Write a Review
SKU:
CAB9264
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-CD82 Antibody
Antibody SKU:CAB9264
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CD82
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HT-29, Jurkat, Raji
Immunogen:A synthesized peptide derived from human CD82
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3732
Uniprot:P27701
Cellular Location:
Calculated MW:30-60kDa
Observed MW:45-50KDa
Synonyms:4F9, C33, GR15, IA4, KAI1, R2, SAR2, ST6, TSPAN27
Background:This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Protein Function:CD82: a widespread transmembrane protein of the tetraspanin family. A metastasis-suppressor whose decreased expression may be involved in malignant progression. Suppresses tumor metastasis of many cancers including cancers of the prostate, bladder, colon, cervix, liver, and lung (NSCLC). It is a target of estrogen receptor-mediated gene repression and is downregulated in primary human breast cancer. May be a prognostic marker for lung cancer and tumor metastatic potential. Interacts with cell surface proteins including integrins, cadherins, CD4, CD8, IGSF8. Modulates EGFR signaling. May suppress invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases. Its regulation of c-Met signaling apparently affects cancer cell migration.
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:protein binding

Disease: Prostate Cancer

NCBI Summary:This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P27701
NCBI GenInfo Identifier:4504813
NCBI Gene ID:3732
NCBI Accession:NP_002222
UniProt Secondary Accession:P27701,Q7Z2D4, Q7Z5N2, D3DQN6, E9PC70,
UniProt Related Accession:P27701
Molecular Weight:26,818 Da
NCBI Full Name:CD82 antigen isoform 1
NCBI Synonym Full Names:CD82 molecule
NCBI Official Symbol:CD82  
NCBI Official Synonym Symbols:R2; 4F9; C33; IA4; ST6; GR15; KAI1; SAR2; TSPAN27  
NCBI Protein Information:CD82 antigen; tspan-27; C33 antigen; tetraspanin-27; inducible membrane protein R2; metastasis suppressor Kangai-1; kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))
UniProt Protein Name:CD82 antigen
UniProt Synonym Protein Names:C33 antigen; IA4; Inducible membrane protein R2; Metastasis suppressor Kangai-1; Suppressor of tumorigenicity 6 protein; Tetraspanin-27; Tspan-27; CD_antigen: CD82
Protein Family:CD82 antigen
UniProt Gene Name:CD82  
UniProt Entry Name:CD82_HUMAN
Anti-CD82 Antibody (CAB9264)Western blot - CD82 Rabbit mAb (CAB9264)
View AllClose

0 Reviews

View AllClose

Related Products

Human CD82/KAI Recombinant Protein (RPES0093)

Human CD82/KAI Recombinant Protein (RPES0093)

system_update_altDatasheetHuman CD82/KAI Recombinant Protein CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional gr