Immunology Antibodies 2
Anti-CD81 Antibody (CAB5270)
- SKU:
- CAB5270
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-CD81 Antibody |
| Antibody SKU: | CAB5270 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CD81 (NP_004347.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Raji, U-87MG |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CD81 (NP_004347.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGVE GCTK CIKY LLFV FNFV FWLA GGVI LGVA LWLR HDPQ TTNL LYLE LGDK PAPN TFYV GIYI LIAV GAVM MFVG FLGC YGAI QESQ CLLG TFFT CLVI |
| Gene ID: | 975 |
| Uniprot: | P60033 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 25kDa |
| Observed MW: | 22KDa |
| Synonyms: | CD81, CVID6, S5.7, TAPA1, TSPAN28 |
| Background: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. |
| NCBI Summary: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
| UniProt Code: | P60033 |
| NCBI GenInfo Identifier: | 38503376 |
| NCBI Gene ID: | 975 |
| NCBI Accession: | P60033.1 |
| UniProt Related Accession: | P60033 |
| Molecular Weight: | |
| NCBI Full Name: | CD81 antigen |
| NCBI Synonym Full Names: | CD81 molecule |
| NCBI Official Symbol: | CD81 |
| NCBI Official Synonym Symbols: | S5.7; CVID6; TAPA1; TSPAN28 |
| NCBI Protein Information: | CD81 antigen |
| UniProt Protein Name: | CD81 antigen |
| UniProt Synonym Protein Names: | 26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28; Tspan-28; CD_antigen: CD81 |
| Protein Family: | CD81 antigen |
| UniProt Gene Name: | CD81 |
 | Western blot analysis of extracts of Rat brain, using CD81 antibody (CAB5270) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Western blot analysis of extracts of various cell lines, using CD81 antibody (CAB5270) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 3min. |
 | Immunohistochemistry of paraffin-embedded mouse lung using CD81 antibody (CAB5270) at dilution of 1:100 (40x lens). |
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