Anti-CD79B Antibody (CAB4362)
- SKU:
- CAB4362
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- AGM6
- Synonyms:
- B29
- Synonyms:
- IGB
- Research Area:
- Immunology
Description
| Product Name: | CD79B Rabbit mAb |
| Product Code: | CAB4362 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | AGM6, B29, IGB |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CD79B |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Raji |
| Immunogen: | A synthesized peptide derived from human CD79B |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 974 |
| Uniprot: | P40259 |
| Calculated MW: | 30-50kDa |
| Observed MW: | 36KDa |
| UniProt Protein Function: | Ig-beta: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 17q23 Cellular Component: nucleoplasm; Golgi apparatus; integral to plasma membrane; cytoplasm; plasma membrane; B cell receptor complex; external side of plasma membrane Molecular Function:transmembrane receptor activity Biological Process: B cell receptor signaling pathway; immune response; signal transduction Disease: Agammaglobulinemia 6, Autosomal Recessive |
| NCBI Summary: | The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P40259 |
| NCBI GenInfo Identifier: | 728994 |
| NCBI Gene ID: | 974 |
| NCBI Accession: | P40259.1 |
| UniProt Secondary Accession: | P40259,Q53FS2, Q9BU06, |
| UniProt Related Accession: | P40259 |
| Molecular Weight: | 229 |
| NCBI Full Name: | B-cell antigen receptor complex-associated protein beta chain |
| NCBI Synonym Full Names: | CD79b molecule, immunoglobulin-associated beta |
| NCBI Official Symbol: | CD79B |
| NCBI Official Synonym Symbols: | B29; IGB; AGM6 |
| NCBI Protein Information: | B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta) |
| UniProt Protein Name: | B-cell antigen receptor complex-associated protein beta chain |
| UniProt Synonym Protein Names: | B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein; CD_antigen: CD79b |
| UniProt Gene Name: | CD79B |
| UniProt Entry Name: | CD79B_HUMAN |
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