Immunology Antibodies 2

Anti-CD79B Antibody (CAB2033)

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SKU:
CAB2033
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:Anti-CD79B Antibody
Antibody SKU:CAB2033
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 29-159 of human CD79B (NP_000617.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human
Positive Samples:Raji
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 29-159 of human CD79B (NP_000617.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ARSE DRYR NPKG SACS RIWQ SPRF IARK RGFT VKMH CYMN SASG NVSW LWKQ EMDE NPQQ LKLE KGRM EESQ NESL ATLT IQGI RFED NGIY FCQQ KCNN TSEV YQGC GTEL RVMG FSTL AQLK QRNT LKD
Gene ID:974
Uniprot:P40259
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:14kDa/26kDa
Observed MW:36kDa
Synonyms:CD79B, AGM6, B29, IGB
Background:The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.
UniProt Protein Function:Ig-beta: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q23

Cellular Component: nucleoplasm; Golgi apparatus; integral to plasma membrane; cytoplasm; plasma membrane; B cell receptor complex; external side of plasma membrane

Molecular Function:transmembrane receptor activity

Biological Process: B cell receptor signaling pathway; immune response; signal transduction

Disease: Agammaglobulinemia 6, Autosomal Recessive

NCBI Summary:The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Code:P40259
NCBI GenInfo Identifier:728994
NCBI Gene ID:974
NCBI Accession:P40259.1
UniProt Secondary Accession:P40259,Q53FS2, Q9BU06,
UniProt Related Accession:P40259
Molecular Weight:229
NCBI Full Name:B-cell antigen receptor complex-associated protein beta chain
NCBI Synonym Full Names:CD79b molecule, immunoglobulin-associated beta
NCBI Official Symbol:CD79B  
NCBI Official Synonym Symbols:B29; IGB; AGM6  
NCBI Protein Information:B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta)
UniProt Protein Name:B-cell antigen receptor complex-associated protein beta chain
UniProt Synonym Protein Names:B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein; CD_antigen: CD79b
UniProt Gene Name:CD79B  
UniProt Entry Name:CD79B_HUMAN
Anti-CD79B Antibody (CAB2033)Western blot analysis of extracts of Raji cells, using CD79B antibody (CAB2033) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020).
Anti-CD79B Antibody (CAB2033)Immunofluorescence analysis of MCF-7 cells using CD79B antibody (CAB2033). Blue: DAPI for nuclear staining.
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