Immunology Antibodies 1

Anti-CD79A Antibody (CAB0331)

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SKU:
CAB0331
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-CD79A Antibody
Antibody SKU:CAB0331
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 33-145 of human CD79A (NP_001774.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:1000 IHC 1:50 - 1:200 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:Raji, Mouse thymus, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 33-145 of human CD79A (NP_001774.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LWMH KVPA SLMV SLGE DAHF QCPH NSSN NANV TWWR VLHG NYTW PPEF LGPG EDPN GTLI IQNV NKSH GGIY VCRV QEGN ESYQ QSCG TYLR VRQP PPRP FLDM GEGT KNRI I
Gene ID:973
Uniprot:P11912
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:20kDa/25kDa
Observed MW:40-50KDa
Synonyms:CD79A, IGA, MB-1, CD79a molecule, CD79a
Background:The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.
UniProt Protein Function:Ig-alpha: an integral membrane protein that associates with surface immunoglobulin B lymphocyte antigen receptor multimeric complex. Surface Ig non-covalently associates with 2 other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. Two alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: B cell receptor complex; cytoplasm; external side of plasma membrane; integral to plasma membrane; lipid raft; multivesicular body; plasma membrane

Molecular Function:protein binding

Biological Process: B cell activation; B cell differentiation; B cell proliferation; B cell receptor signaling pathway

Disease: Agammaglobulinemia 3, Autosomal Recessive

NCBI Summary:The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Code:P11912
NCBI GenInfo Identifier:547896
NCBI Gene ID:973
NCBI Accession:P11912.2
UniProt Secondary Accession:P11912,Q53FB8, A0N775,
UniProt Related Accession:P11912
Molecular Weight:20,786 Da
NCBI Full Name:B-cell antigen receptor complex-associated protein alpha chain
NCBI Synonym Full Names:CD79a molecule
NCBI Official Symbol:CD79A  
NCBI Official Synonym Symbols:IGA; MB-1  
NCBI Protein Information:B-cell antigen receptor complex-associated protein alpha chain
UniProt Protein Name:B-cell antigen receptor complex-associated protein alpha chain
UniProt Synonym Protein Names:Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein; CD_antigen: CD79a
Protein Family:B-cell antigen receptor complex-associated protein
UniProt Gene Name:CD79A  
UniProt Entry Name:CD79A_HUMAN
Anti-CD79A Antibody (CAB0331)Western blot analysis of extracts of Raji cells, using CD79A antibody (CAB0331) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-CD79A Antibody (CAB0331)Western blot analysis of extracts of various cell lines, using CD79A antibody (CAB0331) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-CD79A Antibody (CAB0331)Immunohistochemistry of paraffin-embedded rat spleen using CD79A Rabbit pAb (CAB0331) at dilution of 1:100 (40x lens).
Anti-CD79A Antibody (CAB0331)Immunohistochemistry of paraffin-embedded human spleen using CD79A Rabbit pAb (CAB0331) at dilution of 1:100 (40x lens).
Anti-CD79A Antibody (CAB0331)Immunohistochemistry of paraffin-embedded mouse spleen using CD79A Rabbit pAb (CAB0331) at dilution of 1:100 (40x lens).
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