Immunology Antibodies 3

Anti-CD74 Antibody (CAB9149)

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SKU:
CAB9149
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-CD74 Antibody
Antibody SKU:CAB9149
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CD74
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human
Positive Samples:HepG2, Raji
Immunogen:A synthesized peptide derived from human CD74
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:972
Uniprot:P04233
Cellular Location:
Calculated MW:34kDa
Observed MW:30-40KDa
Synonyms:DHLAG, HLADG, II, Ia-GAMMA
Background:The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
UniProt Protein Function:Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
NCBI Summary:The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
UniProt Code:P04233
NCBI GenInfo Identifier:20178292
NCBI Gene ID:972
NCBI Accession:P04233.3
UniProt Secondary Accession:P04233,Q14597, Q29832, Q5U0J8, Q8SNA0, Q8WLP6, A8K7R1 B4DNE8, D3DQG3, D3DQG4,
UniProt Related Accession:P04233
Molecular Weight:
NCBI Full Name:HLA class II histocompatibility antigen gamma chain
NCBI Synonym Full Names:CD74 molecule
NCBI Official Symbol:CD74  
NCBI Official Synonym Symbols:II; DHLAG; HLADG; Ia-GAMMA  
NCBI Protein Information:HLA class II histocompatibility antigen gamma chain
UniProt Protein Name:HLA class II histocompatibility antigen gamma chain
UniProt Synonym Protein Names:HLA-DR antigens-associated invariant chain; Ia antigen-associated invariant chain; Ii; p33; CD_antigen: CD74
Protein Family:H-2 class II histocompatibility antigen
UniProt Gene Name:CD74  
UniProt Entry Name:HG2A_HUMAN
Anti-CD74 Antibody (CAB9149)Western blot - CD74 Rabbit mAb (CAB9149)
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