Anti-CD70 Antibody (CAB20589)
- SKU:
- CAB20589
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Product Name: | CD70 Rabbit mAb |
| Product Code: | CAB20589 |
| Size: | 50uL, 100uL |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human CD70. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | Raji, 293T |
| Immunogen: | Recombinant protein of human CD70. |
| Purification Method: | Affinity purification |
| Storage: | Store at 4°C (regular) or -20°C (long term). Avoid freeze Buffer: PBS with 0.02% thimerosal, pH7.4. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 970 |
| Uniprot: | P32970 |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | CD70: Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. Belongs to the tumor necrosis factor family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cytokine Chromosomal Location of Human Ortholog: 19p13 Cellular Component: extracellular space; integral to plasma membrane; plasma membrane Molecular Function:protein binding; protease binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding Biological Process: cell proliferation; cell-cell signaling; immune response; signal transduction |
| NCBI Summary: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P32970 |
| NCBI GenInfo Identifier: | 21431837 |
| NCBI Gene ID: | 970 |
| NCBI Accession: | P32970.2 |
| UniProt Secondary Accession: | P32970,Q53XX4, Q96J57, B4DPR8, |
| UniProt Related Accession: | P32970 |
| Molecular Weight: | 193 |
| NCBI Full Name: | CD70 antigen |
| NCBI Synonym Full Names: | CD70 molecule |
| NCBI Official Symbol: | CD70 |
| NCBI Official Synonym Symbols: | CD27L; CD27LG; TNFSF7 |
| NCBI Protein Information: | CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7 |
| UniProt Protein Name: | CD70 antigen |
| UniProt Synonym Protein Names: | CD27 ligand; CD27-L; Tumor necrosis factor ligand superfamily member 7; CD_antigen: CD70 |
| Protein Family: | CD70 antigen |
| UniProt Gene Name: | CD70 |
| UniProt Entry Name: | CD70_HUMAN |
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