Cell Biology Antibodies 7

Anti-CD70 Antibody (CAB16698)

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SKU:
CAB16698
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CD70 Antibody
Antibody SKU:CAB16698
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human CD70.
Application:IF
Recommended Dilution:IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant protein of human CD70.
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:970
Uniprot:P32970
Cellular Location:Membrane, Single-pass type II membrane protein
Calculated MW:21kDa/23kDa
Observed MW:Refer to figures
Synonyms:CD70, CD27-L, CD27L, CD27LG, TNFSF7, TNLG8A
Background:The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
UniProt Protein Function:CD70: Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. Belongs to the tumor necrosis factor family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cytokine

Chromosomal Location of Human Ortholog: 19p13

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane

Molecular Function:protein binding; protease binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: cell proliferation; cell-cell signaling; immune response; signal transduction

NCBI Summary:The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
UniProt Code:P32970
NCBI GenInfo Identifier:21431837
NCBI Gene ID:970
NCBI Accession:P32970.2
UniProt Secondary Accession:P32970,Q53XX4, Q96J57, B4DPR8,
UniProt Related Accession:P32970
Molecular Weight:193
NCBI Full Name:CD70 antigen
NCBI Synonym Full Names:CD70 molecule
NCBI Official Symbol:CD70  
NCBI Official Synonym Symbols:CD27L; CD27LG; TNFSF7  
NCBI Protein Information:CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7
UniProt Protein Name:CD70 antigen
UniProt Synonym Protein Names:CD27 ligand; CD27-L; Tumor necrosis factor ligand superfamily member 7; CD_antigen: CD70
Protein Family:CD70 antigen
UniProt Gene Name:CD70  
UniProt Entry Name:CD70_HUMAN
Anti-CD70 Antibody (CAB16698)Immunofluorescence analysis of rat spleen using CD70 Polyclonal Antibody (CAB16698) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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