Anti-CD3D Antibody (CAB9770)

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SKU:
CAB9770
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CD3-DELTA
Synonyms:
IMD19
Synonyms:
T3D
Research Area:
Immunology

Description

Product Name:CD3D Rabbit mAb
Product Code:CAB9770
Size:20uL, 50uL, 100uL
Synonyms:CD3-DELTA, IMD19, T3D
Applications:WB, IF, FC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CD3D
Applications:WB, IF, FC
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200 FC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat
Immunogen:A synthesized peptide derived from human CD3D
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:915
Uniprot:P04234
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:19kDa
Observed MW:23kDa
UniProt Protein Function:CD3D: a T cell surface glycoprotein that is a component of the T cell antigen receptor. A defect in this protein causes a severe combined immunodeficiency characterized by the absence of T cells but normal B cells. Contains 1 ITAM domain.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: T cell receptor complex; cytoplasm; plasma membrane; integral to membrane; alpha-beta T cell receptor complex

Molecular Function:transmembrane receptor activity; protein heterodimerization activity; transcription coactivator activity

Biological Process: regulation of immune response; cell surface receptor linked signal transduction; T cell costimulation; positive regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway; T cell differentiation; positive thymic T cell selection

Disease: Immunodeficiency 19

NCBI Summary:The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]
UniProt Code:P04234
NCBI GenInfo Identifier:115985
NCBI Gene ID:915
NCBI Accession:P04234.1
UniProt Secondary Accession:P04234,A8MVP6,
UniProt Related Accession:P04234
Molecular Weight:171
NCBI Full Name:T-cell surface glycoprotein CD3 delta chain
NCBI Synonym Full Names:CD3d molecule, delta (CD3-TCR complex)
NCBI Official Symbol:CD3D  
NCBI Official Synonym Symbols:T3D; IMD19; CD3-DELTA  
NCBI Protein Information:T-cell surface glycoprotein CD3 delta chain; OKT3, delta chain; CD3 antigen, delta subunit; T-cell receptor T3 delta chain; CD3d antigen, delta polypeptide (TiT3 complex)
UniProt Protein Name:T-cell surface glycoprotein CD3 delta chain
UniProt Synonym Protein Names:T-cell receptor T3 delta chain; CD_antigen: CD3d
Protein Family:CD302 antigen
UniProt Gene Name:CD3D  
UniProt Entry Name:CD3D_HUMAN
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