Description
| Product Name: | CD3D Rabbit mAb |
| Product Code: | CAB9770 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CD3-DELTA, IMD19, T3D |
| Applications: | WB, IF, FC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CD3D |
| Applications: | WB, IF, FC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 FC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat |
| Immunogen: | A synthesized peptide derived from human CD3D |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 915 |
| Uniprot: | P04234 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 19kDa |
| Observed MW: | 23kDa |
| UniProt Protein Function: | CD3D: a T cell surface glycoprotein that is a component of the T cell antigen receptor. A defect in this protein causes a severe combined immunodeficiency characterized by the absence of T cells but normal B cells. Contains 1 ITAM domain. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 11q23 Cellular Component: T cell receptor complex; cytoplasm; plasma membrane; integral to membrane; alpha-beta T cell receptor complex Molecular Function:transmembrane receptor activity; protein heterodimerization activity; transcription coactivator activity Biological Process: regulation of immune response; cell surface receptor linked signal transduction; T cell costimulation; positive regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway; T cell differentiation; positive thymic T cell selection Disease: Immunodeficiency 19 |
| NCBI Summary: | The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009] |
| UniProt Code: | P04234 |
| NCBI GenInfo Identifier: | 115985 |
| NCBI Gene ID: | 915 |
| NCBI Accession: | P04234.1 |
| UniProt Secondary Accession: | P04234,A8MVP6, |
| UniProt Related Accession: | P04234 |
| Molecular Weight: | 171 |
| NCBI Full Name: | T-cell surface glycoprotein CD3 delta chain |
| NCBI Synonym Full Names: | CD3d molecule, delta (CD3-TCR complex) |
| NCBI Official Symbol: | CD3DÂ Â |
| NCBI Official Synonym Symbols: | T3D; IMD19; CD3-DELTAÂ Â |
| NCBI Protein Information: | T-cell surface glycoprotein CD3 delta chain; OKT3, delta chain; CD3 antigen, delta subunit; T-cell receptor T3 delta chain; CD3d antigen, delta polypeptide (TiT3 complex) |
| UniProt Protein Name: | T-cell surface glycoprotein CD3 delta chain |
| UniProt Synonym Protein Names: | T-cell receptor T3 delta chain; CD_antigen: CD3d |
| Protein Family: | CD302 antigen |
| UniProt Gene Name: | CD3DÂ Â |
| UniProt Entry Name: | CD3D_HUMAN |
