Anti-CD38 Antibody (CAB20215)

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SKU:
CAB20215
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CD38
Synonyms:
ADPRC 1
Synonyms:
ADPRC1
Research Area:
Cell Biology

Description

Product Name:CD38 Rabbit mAb
Product Code:CAB20215
Size:50uL, 100uL
Synonyms:CD38, ADPRC 1, ADPRC1
Applications:IF, FC, ELISA
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human CD38.
Applications:IF, FC, ELISA
Recommended Dilutions:Elisa 1:500 - 1:2000 FC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human
Immunogen:Recombinant protein of human CD38.
Purification Method:Affinity purification
Storage:Store at 4°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:952
Uniprot:P28907
Cellular Location:Membrane, Single-pass type II membrane protein
Calculated MW:13kDa/34kDa
Observed MW:Refer to figures
UniProt Protein Function:CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.2.2.6; EC 2.4.99.20; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Hydrolase; Cell surface; Apoptosis; Lyase; Membrane protein, integral; Cell cycle regulation

Chromosomal Location of Human Ortholog: 4p15

Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; nucleus

Molecular Function:transferase activity; phosphorus-oxygen lyase activity; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity

Biological Process: response to drug; response to retinoic acid; metabolic process; positive regulation of transcription, DNA-dependent; positive regulation of insulin secretion; female pregnancy; signal transduction; positive regulation of cell growth; response to estradiol stimulus; B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; response to hydroperoxide; positive regulation of B cell proliferation; positive regulation of vasoconstriction; response to hypoxia; response to progesterone stimulus; negative regulation of transcription, DNA-dependent; negative regulation of bone resorption; negative regulation of apoptosis

NCBI Summary:CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq, Jul 2008]
UniProt Code:P28907
NCBI GenInfo Identifier:55977782
NCBI Gene ID:952
NCBI Accession:P28907.2
UniProt Secondary Accession:P28907,O00121, O00122, Q96HY4,
UniProt Related Accession:P28907
Molecular Weight:300
NCBI Full Name:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
NCBI Synonym Full Names:CD38 molecule
NCBI Official Symbol:CD38  
NCBI Official Synonym Symbols:T10; ADPRC 1  
NCBI Protein Information:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; CD38 antigen (p45); NAD(+) nucleosidase; ADP-ribosyl cyclase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
UniProt Protein Name:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
UniProt Synonym Protein Names:2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20); 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD_antigen: CD38
Protein Family:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
UniProt Gene Name:CD38  
UniProt Entry Name:CD38_HUMAN
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