Cell Biology Antibodies 7

Anti-CD38 Antibody (CAB1680)

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SKU:
CAB1680
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CD38 Antibody
Antibody SKU:CAB1680
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CD38 (NP_001766.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HL-60, HeLa, THP-1, H-P, Mouse liver, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CD38 (NP_001766.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MANC EFSP VSGD KPCC RLSR RAQL CLGV SILV LILV VVLA VVVP RWRQ QWSG PGTT KRFP ETVL ARCV KYTE IHPE MRHV DCQS VWDA FKGA FISK HPCN ITEE DYQP LMKL GTQT VPCN KILL WSRI KDLA HQFT QVQR DMFT LEDT LLGY LADD LTWC GEFN TSKI NYQS CPDW RKDC SNNP VSVF WKTV SRRF AEAA CDVV HVML NGSR SKIF DKNS TFGS VEVH NLQP EKVQ TLEA WVIH GGRE DSRD LCQD PTIK ELES IISK RNIQ FSCK NIYR PDKF LQCV KNPE DSSC TSEI
Gene ID:952
Uniprot:P28907
Cellular Location:Membrane, Single-pass type II membrane protein
Calculated MW:13kDa/34kDa
Observed MW:45kDa
Synonyms:CD38, ADPRC 1, ADPRC1
Background:The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.2.2.6; EC 2.4.99.20; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Hydrolase; Cell surface; Apoptosis; Lyase; Membrane protein, integral; Cell cycle regulation

Chromosomal Location of Human Ortholog: 4p15

Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; nucleus

Molecular Function:transferase activity; phosphorus-oxygen lyase activity; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity

Biological Process: response to drug; response to retinoic acid; metabolic process; positive regulation of transcription, DNA-dependent; positive regulation of insulin secretion; female pregnancy; signal transduction; positive regulation of cell growth; response to estradiol stimulus; B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; response to hydroperoxide; positive regulation of B cell proliferation; positive regulation of vasoconstriction; response to hypoxia; response to progesterone stimulus; negative regulation of transcription, DNA-dependent; negative regulation of bone resorption; negative regulation of apoptosis

NCBI Summary:CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq, Jul 2008]
UniProt Code:P28907
NCBI GenInfo Identifier:55977782
NCBI Gene ID:952
NCBI Accession:P28907.2
UniProt Secondary Accession:P28907,O00121, O00122, Q96HY4,
UniProt Related Accession:P28907
Molecular Weight:300
NCBI Full Name:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
NCBI Synonym Full Names:CD38 molecule
NCBI Official Symbol:CD38  
NCBI Official Synonym Symbols:T10; ADPRC 1  
NCBI Protein Information:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; CD38 antigen (p45); NAD(+) nucleosidase; ADP-ribosyl cyclase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
UniProt Protein Name:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
UniProt Synonym Protein Names:2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20); 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD_antigen: CD38
Protein Family:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
UniProt Gene Name:CD38  
UniProt Entry Name:CD38_HUMAN
Anti-CD38 Antibody (CAB1680)Western blot analysis of extracts of various cell lines, using CD38 Antibody (CAB1680) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-CD38 Antibody (CAB1680)Immunofluorescence analysis of THP-1 cells using CD38 antibody (CAB1680) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-CD38 Antibody (CAB1680)Immunofluorescence analysis of Mouse spleen using CD38 antibody (CAB1680) at dilution of 1:100. Blue: DAPI for nuclear staining.
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