Description
| Product Name: | CD35/CR1 Rabbit mAb |
| Product Code: | CAB3661 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | C3BR, C4BR, CD35, KN |
| Applications: | IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CD35/CR1 |
| Applications: | IHC, IF |
| Recommended Dilutions: | IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | A synthesized peptide derived from human CD35/CR1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1378 |
| Uniprot: | P17927 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 280kDa |
| UniProt Protein Function: | CR1: Mediates cellular binding of particles and immune complexes that have activated complement. Belongs to the receptors of complement activation (RCA) family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q32 Cellular Component: cell surface; integral to plasma membrane; plasma membrane Molecular Function:complement component C3b receptor activity; complement component C4b binding; complement component C4b receptor activity; complement component C3b binding Biological Process: negative regulation of complement activation, alternative pathway; complement receptor mediated signaling pathway; negative regulation of complement activation, classical pathway; regulation of complement activation; innate immune response; complement activation, classical pathway Disease: Knops Blood Group System; Malaria, Susceptibility To |
| NCBI Summary: | This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P17927 |
| NCBI GenInfo Identifier: | 86793036 |
| NCBI Gene ID: | 1378 |
| NCBI Accession: | NP_000564.2 |
| UniProt Secondary Accession: | P17927,Q16744, Q16745, Q5SR43, Q5SR45, Q9UQV2, |
| UniProt Related Accession: | P17927 |
| Molecular Weight: | 223,663 Da |
| NCBI Full Name: | complement receptor type 1 isoform F |
| NCBI Synonym Full Names: | complement component (3b/4b) receptor 1 (Knops blood group) |
| NCBI Official Symbol: | CR1Â Â |
| NCBI Official Synonym Symbols: | KN; C3BR; C4BR; CD35Â Â |
| NCBI Protein Information: | complement receptor type 1 |
| UniProt Protein Name: | Complement receptor type 1 |
| UniProt Synonym Protein Names: | C3b/C4b receptor; CD_antigen: CD35 |
| Protein Family: | Complement receptor |
| UniProt Gene Name: | CR1Â Â |
| UniProt Entry Name: | CR1_HUMAN |
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