Anti-CD35/CR1 Antibody (CAB3661)

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SKU:
CAB3661
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
C3BR
Synonyms:
C4BR
Synonyms:
CD35
Synonyms:
KN
Research Area:
Immunology

Description

Product Name:CD35/CR1 Rabbit mAb
Product Code:CAB3661
Size:20uL, 50uL, 100uL
Synonyms:C3BR, C4BR, CD35, KN
Applications:IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CD35/CR1
Applications:IHC, IF
Recommended Dilutions:IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Immunogen:A synthesized peptide derived from human CD35/CR1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1378
Uniprot:P17927
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:280kDa
UniProt Protein Function:CR1: Mediates cellular binding of particles and immune complexes that have activated complement. Belongs to the receptors of complement activation (RCA) family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: cell surface; integral to plasma membrane; plasma membrane

Molecular Function:complement component C3b receptor activity; complement component C4b binding; complement component C4b receptor activity; complement component C3b binding

Biological Process: negative regulation of complement activation, alternative pathway; complement receptor mediated signaling pathway; negative regulation of complement activation, classical pathway; regulation of complement activation; innate immune response; complement activation, classical pathway

Disease: Knops Blood Group System; Malaria, Susceptibility To

NCBI Summary:This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
UniProt Code:P17927
NCBI GenInfo Identifier:86793036
NCBI Gene ID:1378
NCBI Accession:NP_000564.2
UniProt Secondary Accession:P17927,Q16744, Q16745, Q5SR43, Q5SR45, Q9UQV2,
UniProt Related Accession:P17927
Molecular Weight:223,663 Da
NCBI Full Name:complement receptor type 1 isoform F
NCBI Synonym Full Names:complement component (3b/4b) receptor 1 (Knops blood group)
NCBI Official Symbol:CR1  
NCBI Official Synonym Symbols:KN; C3BR; C4BR; CD35  
NCBI Protein Information:complement receptor type 1
UniProt Protein Name:Complement receptor type 1
UniProt Synonym Protein Names:C3b/C4b receptor; CD_antigen: CD35
Protein Family:Complement receptor
UniProt Gene Name:CR1  
UniProt Entry Name:CR1_HUMAN
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