Cell Biology Antibodies 12

Anti-CD320 antigen Antibody (CAB8627)

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SKU:
CAB8627
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-CD320 antigen Antibody
Antibody SKU:CAB8627
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 36-229 of human CD320 (NP_057663.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 36-229 of human CD320 (NP_057663.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SPLS TPTS AQAA GPSS GSCP PTKF QCRT SGLC VPLT WRCD RDLD CSDG SDEE ECRI EPCT QKGQ CPPP PGLP CPCT GVSD CSGG TDKK LRNC SRLA CLAG ELRC TLSD DCIP LTWR CDGH PDCP DSSD ELGC GTNE ILPE GDAT TMGP PVTL ESVT SLRN ATTM GPPV TLES VPSV GNAT SSSA GDQS GSPT AY
Gene ID:51293
Uniprot:Q9NPF0
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:24kDa/28kDa
Observed MW:30kDa
Synonyms:CD320, 8D6, 8D6A, TCBLR
Background:This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:Receptor for transcobalamin saturated with cobalamin (TCbl) (PubMed:18779389). Plays an important role in cobalamin uptake (PubMed:18779389, PubMed:20524213). Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells (PubMed:10727470). Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation (PubMed:10727470, PubMed:11418631). Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) (PubMed:11418631). CD320 augments the proliferation of PC precursors generated by IL-10 (PubMed:11418631).
NCBI Summary:This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
UniProt Code:Q9NPF0
NCBI GenInfo Identifier:74734303
NCBI Gene ID:51293
NCBI Accession:Q9NPF0.1
UniProt Secondary Accession:Q9NPF0,Q53HF7, B2RDS5, D6W668, F5H6D3,
UniProt Related Accession:Q9NPF0
Molecular Weight:24,371 Da
NCBI Full Name:CD320 antigen
NCBI Synonym Full Names:CD320 molecule
NCBI Official Symbol:CD320  
NCBI Official Synonym Symbols:8D6; 8D6A; TCBLR  
NCBI Protein Information:CD320 antigen
UniProt Protein Name:CD320 antigen
UniProt Synonym Protein Names:8D6 antigen
Protein Family:CD320 antigen
UniProt Gene Name:CD320  
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