Cell Biology Antibodies 8
Anti-CD31/PECAM1 Antibody (CAB3181)
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- SKU:
- CAB3181
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CD31/PECAM1 Antibody |
| Antibody SKU: | CAB3181 |
| Antibody Size: | 20µL, 50µL |
| Application: | WB IHC IP |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 600 to the C-terminus of mouse CD31/PECAM1 (NP_001292086.1). |
| Application: | WB IHC IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Jurkat, THP-1, Mouse testis, Mouse lung, Mouse heart |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 600 to the C-terminus of mouse CD31/PECAM1 (NP_001292086.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VVIA TLIV AAKC YFLR KAKA KQKP VEMS RPAA PLLN SNSE KISE PSVE ANSH YGYD DVSG NDAV KPIN QNKD PQNM DVEY TEVE VSSL EPHQ ALGT RATE TVYS EIRK VDPN LMEN RYSR TEGS LNGT |
| Gene ID: | 18613 |
| Uniprot: | Q08481 |
| Cellular Location: | Cell junction, Cell junction, Cell membrane, Lipid-anchor, Single-pass type I membrane protein |
| Calculated MW: | 79kDa/80kDa/81kDa/82kDa |
| Observed MW: | 130kDa |
| Synonyms: | PECAM1, CD31, CD31/EndoCAM, GPIIA, PECA1, PECAM-1, endoCAM |
| Background: | The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. |
| UniProt Protein Function: | PECAM-1: a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral Cellular Component: extracellular space; cell surface; smooth muscle contractile fiber; membrane; integral to membrane; plasma membrane; intracellular; cell junction; lipid raft; external side of plasma membrane Molecular Function:protein binding Biological Process: negative regulation of peptidyl-tyrosine phosphorylation; wound healing; positive regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of actin filament polymerization; positive regulation of leukocyte migration; diapedesis; cell adhesion; regulation of cell migration; phagocytosis; Rho protein signal transduction |
| UniProt Code: | Q08481 |
| NCBI GenInfo Identifier: | 585658 |
| NCBI Gene ID: | 18613 |
| NCBI Accession: | Q08481.1 |
| UniProt Related Accession: | Q08481 |
| Molecular Weight: | |
| NCBI Full Name: | Platelet endothelial cell adhesion molecule |
| NCBI Synonym Full Names: | platelet/endothelial cell adhesion molecule 1 |
| NCBI Official Symbol: | Pecam1 |
| NCBI Official Synonym Symbols: | Cd31; Pecam; C85791; PECAM-1 |
| NCBI Protein Information: | platelet endothelial cell adhesion molecule |
| UniProt Protein Name: | Platelet endothelial cell adhesion molecule |
| UniProt Synonym Protein Names: | CD_antigen: CD31 |
| UniProt Gene Name: | Pecam1 |
| UniProt Entry Name: | PECA1_MOUSE |
 | Western blot analysis of extracts of various cell lines, using CD31/PECAM1 antibody (CAB3181) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 3s. |
 | Immunohistochemistry of paraffin-embedded human prostate cancer using CD31/PECAM1 antibody (CAB3181) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human esophagus using CD31/PECAM1 antibody (CAB3181) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using CD31/PECAM1 antibody (CAB3181) at dilution of 1:100 (40x lens). |
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