Cell Biology Antibodies 8
Anti-CD31/PECAM1 Antibody (CAB2104)
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- SKU:
- CAB2104
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CD31/PECAM1 Antibody |
| Antibody SKU: | CAB2104 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 130-230 of human CD31/PECAM1 (NP_000433.4). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | THP-1 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 130-230 of human CD31/PECAM1 (NP_000433.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VPSP RVTL DKKE AIQG GIVR VNCS VPEE KAPI HFTI EKLE LNEK MVKL KREK NSRD QNFV ILEF PVEE QDRV LSFR CQAR IISG IHMQ TSES TKSE LVTV T |
| Gene ID: | 5175 |
| Uniprot: | P16284 |
| Cellular Location: | Cell junction, Cell junction, Cell membrane, Lipid-anchor, Single-pass type I membrane protein |
| Calculated MW: | 79kDa/80kDa/81kDa/82kDa |
| Observed MW: | 130kDa |
| Synonyms: | CD31, CD31/EndoCAM, PECA1, PECAM-1, endoCAM, PECAM1 |
| Background: | The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. |
| UniProt Protein Function: | PECAM-1: a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 17q23.3 Cellular Component: cell junction; extracellular space; integral to membrane; lipid raft; plasma membrane; platelet alpha granule membrane Molecular Function:protein binding Biological Process: blood coagulation; cell adhesion; cell recognition; diapedesis; extracellular matrix organization and biogenesis; leukocyte migration; phagocytosis; platelet activation; platelet degranulation; signal transduction |
| NCBI Summary: | The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010] |
| UniProt Code: | P16284 |
| NCBI GenInfo Identifier: | 129747 |
| NCBI Gene ID: | 5175 |
| NCBI Accession: | P16284.1 |
| UniProt Secondary Accession: | P16284,Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7 Q9NPG9, Q9NQS9, Q9NQT0, A8K3S7, D3DU31, |
| UniProt Related Accession: | P16284 |
| Molecular Weight: | 81,378 Da |
| NCBI Full Name: | Platelet endothelial cell adhesion molecule |
| NCBI Synonym Full Names: | platelet and endothelial cell adhesion molecule 1 |
| NCBI Official Symbol: | PECAM1 |
| NCBI Official Synonym Symbols: | CD31; PECA1; GPIIA'; PECAM-1; endoCAM; CD31/EndoCAM |
| NCBI Protein Information: | platelet endothelial cell adhesion molecule |
| UniProt Protein Name: | Platelet endothelial cell adhesion molecule |
| UniProt Synonym Protein Names: | EndoCAM; GPIIA'; PECA1; CD_antigen: CD31 |
| Protein Family: | Platelet endothelial cell adhesion molecule |
| UniProt Gene Name: | PECAM1 |
| UniProt Entry Name: | PECA1_HUMAN |
 | Western blot analysis of extracts of THP-1 cells, using CD31/PECAM1 antibody (CAB2104) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded Human placenta using CD31/PECAM1 Rabbit pAb (CAB2104) at dilution of 1:100 (40x lens). |
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