KO Validated Antibodies 2

Anti-CD2BP2 Antibody (CAB19891)[KO Validated]

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SKU:
CAB19891
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-CD2BP2 Antibody [KO Validated]
Antibody SKU:CAB19891
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human CD2BP2.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:293T
Immunogen:Recombinant protein of human CD2BP2.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10421
Uniprot:O95400
Cellular Location:Cytoplasm, Nucleus
Calculated MW:37kDa
Observed MW:50KDa
Anti-CD2BP2 Antibody [KO Validated] (CAB19891)Western blot analysis of extracts from normal (control) and CD2BP2 knockout (KO) 293T cells, using CD2BP2 antibody (CAB19891) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Synonyms:CD2BP2, FWP010, LIN1, PPP1R59, Snu40, U5-52K
Background:This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined.
UniProt Protein Function:CD2BP2: Binds the cytoplasmic domain of CD2 through the GYF domain.
UniProt Protein Details:

Protein type:RNA processing; Adaptor/scaffold; Spliceosome

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoplasm; nuclear speck; nucleoplasm; nucleus; snRNP U5; U4/U6 x U5 tri-snRNP complex

Molecular Function:protein binding; ribonucleoprotein binding

Biological Process: nuclear mRNA splicing, via spliceosome

NCBI Summary:This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]
UniProt Code:O95400
NCBI GenInfo Identifier:31339956
NCBI Gene ID:10421
NCBI Accession:O95400.1
UniProt Secondary Accession:O95400,Q9ULP2, B2RDX2,
UniProt Related Accession:O95400
Molecular Weight:37,646 Da
NCBI Full Name:CD2 antigen cytoplasmic tail-binding protein 2
NCBI Synonym Full Names:CD2 cytoplasmic tail binding protein 2
NCBI Official Symbol:CD2BP2  
NCBI Official Synonym Symbols:LIN1; Snu40; FWP010; U5-52K; PPP1R59  
NCBI Protein Information:CD2 antigen cytoplasmic tail-binding protein 2
UniProt Protein Name:CD2 antigen cytoplasmic tail-binding protein 2
UniProt Synonym Protein Names:U5 snRNP 52K protein; U5-52K
Protein Family:CD2 antigen cytoplasmic tail-binding protein
UniProt Gene Name:CD2BP2  
UniProt Entry Name:CD2B2_HUMAN
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