Description
Product Name: | CD28 Rabbit mAb |
Product Code: | CAB20346 |
Size: | 50uL, 100uL |
Synonyms: | Tp44 |
Applications: | WB, FC, ELISA |
Reactivity: | Human, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant protein of human CD28. |
Applications: | WB, FC, ELISA |
Recommended Dilutions: | WB 1:500 - 1:2000 Elisa 1:500 - 1:2000 FC 1:50 - 1:200 |
Reactivity: | Human, Rat |
Positive Samples: | Jurkat, U-937, Mouse spleen, Mouse thymus, Rat spleen |
Immunogen: | Recombinant protein of human CD28. |
Purification Method: | Affinity purification |
Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% sodium azide, pH7.4. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 940 |
Uniprot: | P10747 |
Calculated MW: | 25kDa |
Observed MW: | 45KDa |
UniProt Protein Function: | Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). |
NCBI Summary: | The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] |
UniProt Code: | P10747 |
NCBI GenInfo Identifier: | 115973 |
NCBI Gene ID: | 940 |
NCBI Accession: | P10747.1 |
UniProt Secondary Accession: | P10747,Q13964, Q52M23, Q70WG0, Q8NI54, Q8NI55, Q8NI56 Q8WXJ2, Q9BYV0, A8KAC1, |
UniProt Related Accession: | P10747 |
Molecular Weight: | 26,186 Da |
NCBI Full Name: | T-cell-specific surface glycoprotein CD28 |
NCBI Synonym Full Names: | CD28 molecule |
NCBI Official Symbol: | CD28 |
NCBI Official Synonym Symbols: | Tp44 |
NCBI Protein Information: | T-cell-specific surface glycoprotein CD28 |
UniProt Protein Name: | T-cell-specific surface glycoprotein CD28 |
UniProt Synonym Protein Names: | TP44; CD_antigen: CD28 |
Protein Family: | T-cell-specific surface glycoprotein |
UniProt Gene Name: | CD28 |