Anti-CD28 Antibody (CAB20346)
- SKU:
- CAB20346
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- Tp44
- Research Area:
- Cell Biology
Description
| Product Name: | CD28 Rabbit mAb |
| Product Code: | CAB20346 |
| Size: | 50uL, 100uL |
| Synonyms: | Tp44 |
| Applications: | WB, FC, ELISA |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human CD28. |
| Applications: | WB, FC, ELISA |
| Recommended Dilutions: | WB 1:500 - 1:2000 Elisa 1:500 - 1:2000 FC 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | Jurkat, U-937, Mouse spleen, Mouse thymus, Rat spleen |
| Immunogen: | Recombinant protein of human CD28. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% sodium azide, pH7.4. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 940 |
| Uniprot: | P10747 |
| Calculated MW: | 25kDa |
| Observed MW: | 45KDa |
| UniProt Protein Function: | Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). |
| NCBI Summary: | The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] |
| UniProt Code: | P10747 |
| NCBI GenInfo Identifier: | 115973 |
| NCBI Gene ID: | 940 |
| NCBI Accession: | P10747.1 |
| UniProt Secondary Accession: | P10747,Q13964, Q52M23, Q70WG0, Q8NI54, Q8NI55, Q8NI56 Q8WXJ2, Q9BYV0, A8KAC1, |
| UniProt Related Accession: | P10747 |
| Molecular Weight: | 26,186 Da |
| NCBI Full Name: | T-cell-specific surface glycoprotein CD28 |
| NCBI Synonym Full Names: | CD28 molecule |
| NCBI Official Symbol: | CD28 |
| NCBI Official Synonym Symbols: | Tp44 |
| NCBI Protein Information: | T-cell-specific surface glycoprotein CD28 |
| UniProt Protein Name: | T-cell-specific surface glycoprotein CD28 |
| UniProt Synonym Protein Names: | TP44; CD_antigen: CD28 |
| Protein Family: | T-cell-specific surface glycoprotein |
| UniProt Gene Name: | CD28 |
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