Anti-CD274 Antibody (CAB20481)
- SKU:
- CAB20481
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PD-
- Synonyms:
- B7h1
- Synonyms:
- Pdl1
- Synonyms:
- Pdcd1l
- Synonyms:
- Pdcd1l1
- Synonyms:
- Pdcd1lg1
- Synonyms:
- A530045L16Rik
Description
| Product Name: | CD274 Rabbit pAb |
| Product Code: | CAB20481 |
| Size: | 50uL, 100uL |
| Synonyms: | PD-, B7h1, Pdl1, Pdcd1l, Pdcd1l1, Pdcd1lg1, A530045L16Rik |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of Mouse CD274. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, Mouse skeletal muscle, Rat skeletal muscle |
| Immunogen: | Recombinant protein of Mouse CD274. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 60533 |
| Uniprot: | Q9EP73 |
| Calculated MW: | 32kDa |
| Observed MW: | 40-50KDa |
| UniProt Protein Function: | Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. |
| NCBI Summary: | The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q9EP73 |
| NCBI GenInfo Identifier: | 83287885 |
| NCBI Gene ID: | 60533 |
| NCBI Accession: | Q9EP73.1 |
| UniProt Related Accession: | Q9EP73 |
| Molecular Weight: | 32,780 Da |
| NCBI Full Name: | Programmed cell death 1 ligand 1 |
| NCBI Synonym Full Names: | CD274 antigen |
| NCBI Official Symbol: | Cd274 |
| NCBI Official Synonym Symbols: | B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik |
| NCBI Protein Information: | programmed cell death 1 ligand 1 |
| UniProt Protein Name: | Programmed cell death 1 ligand 1 |
| UniProt Synonym Protein Names: | B7 homolog 1; B7-H1; CD_antigen: CD274 |
| Protein Family: | Programmed cell death |
| UniProt Gene Name: | Cd274 |
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