Description
system_update_altDatasheet
| Product Code: | HDLA022 |
| Size: | 100 µg |
| Clonality: | Monoclonal |
| Clone: | DM59 |
| Synonyms: | CD27, TNFRSF7, S152, T14, Tp55 |
| Applications: | ELISA, Flow Cyt |
| Recommended Dilution: | ELISA 1:5000-10000; Flow Cyt 1:100 |
| Host Species: | Rabbit |
| Isotype: | Rabbit IgG |
| Reactivity: | Human |
| Purification Method: | Purified from cell culture supernatant by affinity chromatography |
| Formulation: | Powder |
| Buffer: | 1XPBS |
| Storage: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature. |
| Usage: | Research use only |
| Background: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. |