Cell Death Antibodies 2
Anti-CD27 Antibody (CAB11505)
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- SKU:
- CAB11505
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-CD27 Antibody |
| Antibody SKU: | CAB11505 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CD27 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | THP-1, Rat thymus |
| Immunogen: | A synthesized peptide derived from human CD27 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 939 |
| Uniprot: | P26842 |
| Cellular Location: | |
| Calculated MW: | 55kDa |
| Observed MW: | 55KDa |
 | Western blot - CD27 Rabbit mAb (CAB11505) |
| Synonyms: | S152, S152. LPFS2, T14, TNFRSF7, Tp55 |
| Background: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | CD27: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Apoptosis; Receptor, cytokine Chromosomal Location of Human Ortholog: 12p13 Cellular Component: integral to plasma membrane; neuron projection; nucleus; plasma membrane Molecular Function:caspase inhibitor activity; protein binding; tumor necrosis factor receptor activity Biological Process: brain development; immune response; induction of apoptosis via death domain receptors; inflammatory response; negative regulation of apoptosis; positive regulation of JNK cascade; positive regulation of MAPKKK cascade; regulation of cell proliferation; response to lipopolysaccharide; tumor necrosis factor-mediated signaling pathway Disease: Lymphoproliferative Syndrome 2 |
| NCBI Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P26842 |
| NCBI GenInfo Identifier: | 269849546 |
| NCBI Gene ID: | 939 |
| NCBI Accession: | P26842.2 |
| UniProt Secondary Accession: | P26842,B2RDZ0, |
| UniProt Related Accession: | P26842 |
| Molecular Weight: | 29,137 Da |
| NCBI Full Name: | CD27 antigen |
| NCBI Synonym Full Names: | CD27 molecule |
| NCBI Official Symbol: | CD27 |
| NCBI Official Synonym Symbols: | T14; S152; Tp55; TNFRSF7; S152. LPFS2 |
| NCBI Protein Information: | CD27 antigen |
| UniProt Protein Name: | CD27 antigen |
| UniProt Synonym Protein Names: | CD27L receptor; T-cell activation antigen CD27; T14; Tumor necrosis factor receptor superfamily member 7; CD_antigen: CD27 |
| Protein Family: | CD27 antigen |
| UniProt Gene Name: | CD27 |
| UniProt Entry Name: | CD27_HUMAN |
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