Cell Death Antibodies 2

Anti-CD27 Antibody (CAB11505)

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SKU:
CAB11505
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-CD27 Antibody
Antibody SKU:CAB11505
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CD27
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:THP-1, Rat thymus
Immunogen:A synthesized peptide derived from human CD27
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:939
Uniprot:P26842
Cellular Location:
Calculated MW:55kDa
Observed MW:55KDa
Anti-CD27 AntibodyWestern blot - CD27 Rabbit mAb (CAB11505)
Synonyms:S152, S152. LPFS2, T14, TNFRSF7, Tp55
Background:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
UniProt Protein Function:CD27: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
UniProt Protein Details:

Protein type:Membrane protein, integral; Apoptosis; Receptor, cytokine

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: integral to plasma membrane; neuron projection; nucleus; plasma membrane

Molecular Function:caspase inhibitor activity; protein binding; tumor necrosis factor receptor activity

Biological Process: brain development; immune response; induction of apoptosis via death domain receptors; inflammatory response; negative regulation of apoptosis; positive regulation of JNK cascade; positive regulation of MAPKKK cascade; regulation of cell proliferation; response to lipopolysaccharide; tumor necrosis factor-mediated signaling pathway

Disease: Lymphoproliferative Syndrome 2

NCBI Summary:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
UniProt Code:P26842
NCBI GenInfo Identifier:269849546
NCBI Gene ID:939
NCBI Accession:P26842.2
UniProt Secondary Accession:P26842,B2RDZ0,
UniProt Related Accession:P26842
Molecular Weight:29,137 Da
NCBI Full Name:CD27 antigen
NCBI Synonym Full Names:CD27 molecule
NCBI Official Symbol:CD27  
NCBI Official Synonym Symbols:T14; S152; Tp55; TNFRSF7; S152. LPFS2  
NCBI Protein Information:CD27 antigen
UniProt Protein Name:CD27 antigen
UniProt Synonym Protein Names:CD27L receptor; T-cell activation antigen CD27; T14; Tumor necrosis factor receptor superfamily member 7; CD_antigen: CD27
Protein Family:CD27 antigen
UniProt Gene Name:CD27  
UniProt Entry Name:CD27_HUMAN
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