Cell Biology Antibodies 17

Anti-CD26 Antibody (CAB4252)

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SKU:
CAB4252
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG

Description

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Antibody Name:Anti-CD26 Antibody
Antibody SKU:CAB4252
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CD26
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-937, Mouse liver, Rat lung, Rat liver, Rat kidney
Immunogen:A synthesized peptide derived from human CD26
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1803
Uniprot:P27487
Cellular Location:
Calculated MW:110kDa
Observed MW:105KDa
Synonyms:ADABP, ADCP2, CD26, DPPIV, TP103
Background:The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]
UniProt Protein Function:DPP4: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Belongs to the peptidase S9B family. DPPIV subfamily.
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, integral; Cell adhesion; Protease; EC 3.4.14.5

Chromosomal Location of Human Ortholog: 2q24.3

Cellular Component: intercellular canaliculus; cell surface; focal adhesion; membrane; endocytic vesicle; lysosomal membrane; lamellipodium; apical plasma membrane; integral to membrane; plasma membrane; lipid raft

Molecular Function:identical protein binding; protein binding; protein homodimerization activity; protease binding; dipeptidyl-peptidase activity; serine-type peptidase activity; serine-type endopeptidase activity; receptor binding

Biological Process: regulation of cell-cell adhesion mediated by integrin; T cell activation; positive regulation of cell proliferation; T cell costimulation; response to hypoxia; endothelial cell migration; proteolysis

NCBI Summary:The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]
UniProt Code:P27487
NCBI GenInfo Identifier:1352311
NCBI Gene ID:1803
NCBI Accession:P27487.2
UniProt Secondary Accession:P27487,Q53TN1,
UniProt Related Accession:P27487
Molecular Weight:88,279 Da
NCBI Full Name:Dipeptidyl peptidase 4
NCBI Synonym Full Names:dipeptidyl-peptidase 4
NCBI Official Symbol:DPP4  
NCBI Official Synonym Symbols:CD26; ADABP; ADCP2; DPPIV; TP103  
NCBI Protein Information:dipeptidyl peptidase 4; ADCP-2; DPP IV; dipeptidylpeptidase 4; dipeptidyl peptidase IV; T-cell activation antigen CD26; adenosine deaminase complexing protein 2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
UniProt Protein Name:Dipeptidyl peptidase 4
UniProt Synonym Protein Names:ADABP; Adenosine deaminase complexing protein 2; ADCP-2; Dipeptidyl peptidase IV; DPP IV; T-cell activation antigen CD26; TP103; CD_antigen: CD26Cleaved into the following 2 chains:Dipeptidyl peptidase 4 membrane formAlternative name(s):Dipeptidyl peptidase IV membrane form
Protein Family:Dipeptidyl peptidase
UniProt Gene Name:DPP4  
UniProt Entry Name:DPP4_HUMAN
Anti-CD26 Antibody (CAB4252)Western blot - CD26 Rabbit mAb (CAB4252)
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